Esover
Generic Name
Esomeprazole 40 mg
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| esover 40 mg capsule | ৳ 9.03 | ৳ 90.30 |
Description
Overview of the medicine
Esomeprazole is a proton pump inhibitor (PPI) that effectively reduces the amount of acid produced in the stomach. It is used to treat conditions such as gastroesophageal reflux disease (GERD), stomach ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
For GERD: 20-40 mg once daily for 4-8 weeks. For erosive esophagitis: 40 mg once daily for 4-8 weeks. For H. pylori eradication: 40 mg once daily with appropriate antibiotics for 10 days.
Elderly
No dosage adjustment is generally required for elderly patients, but caution should be exercised in those with severe hepatic impairment.
Renal_impairment
No dosage adjustment is necessary for patients with mild to moderate renal impairment. For severe renal impairment, monitor with caution.
How to Take
Take the capsule whole with water, at least one hour before a meal. Do not chew or crush the capsule.
Mechanism of Action
Esomeprazole works by irreversibly binding to and inhibiting the H+/K+-ATPase enzyme (the proton pump) in the parietal cells of the stomach. This action blocks the final step in gastric acid secretion, significantly reducing acid production.
Pharmacokinetics
Onset
Within 1 hour of administration.
Excretion
Mainly excreted via urine (approximately 80%) and feces (approximately 20%).
Half life
Approximately 1-1.5 hours.
Absorption
Rapidly absorbed after oral administration; peak plasma concentration (Cmax) achieved within 1-2 hours.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 enzyme system, primarily CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation
- Concomitant use with nelfinavir
Drug Interactions
Diazepam
May decrease the metabolism of diazepam.
Warfarin
May increase INR and prothrombin time; close monitoring is recommended.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel by inhibiting its conversion to active metabolite.
Methotrexate
May increase plasma concentrations of methotrexate; consider temporary withdrawal of PPI.
Nelfinavir/Atazanavir
Decreased plasma concentrations of antiretrovirals; concomitant use is contraindicated with nelfinavir.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptoms may include drowsiness, tachycardia, nausea, diarrhea, headache. Treatment should be symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed and potential benefits outweigh risks. It is unknown whether esomeprazole is excreted in human milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Esomeprazole has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in treating GERD, healing erosive esophagitis, and eradicating H. pylori.
Lab Monitoring
- Routine lab monitoring is generally not required. However, consider monitoring serum magnesium levels with prolonged use (≥3 months) or if taken with other magnesium-reducing drugs. Liver function tests may be monitored in patients with severe hepatic impairment.
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with the patient's condition.
- Periodically reassess the need for continued PPI therapy, especially for long-term users.
- Be aware of potential drug interactions, particularly with clopidogrel and methotrexate.
- Monitor for symptoms of hypomagnesemia and vitamin B12 deficiency in long-term users.
Patient Guidelines
- Take the capsule at least one hour before a meal.
- Do not crush or chew the capsule; swallow it whole.
- Inform your doctor about all other medications you are taking.
- Report any unusual or severe side effects to your doctor.
- Long-term use may increase the risk of certain bone fractures and C. difficile associated diarrhea.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Esomeprazole may cause dizziness or visual disturbances in some individuals. If you experience these side effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid foods and beverages that trigger your acid reflux symptoms (e.g., spicy foods, caffeine, alcohol, fatty foods).
- Maintain a healthy weight.
- Avoid lying down immediately after eating.
- Elevate the head of your bed.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.