Esozol
Generic Name
Esomeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| esozol 20 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Esozol 20 mg Tablet contains Esomeprazole, a proton pump inhibitor used to reduce stomach acid production. It treats conditions like GERD, ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
GERD: 20-40 mg once daily for 4-8 weeks. Erosive Esophagitis: 20-40 mg once daily for 4-8 weeks. Ulcers: 20 mg once daily for 4-8 weeks. Zollinger-Ellison Syndrome: Initial 40 mg twice daily, adjusted as needed.
Elderly
No dose adjustment generally required, but caution in severely impaired hepatic function.
Renal_impairment
No dose adjustment generally required.
How to Take
Take orally, preferably at least one hour before a meal. Swallow the tablet whole; do not chew or crush. For patients who cannot swallow, tablets can be dispersed in water.
Mechanism of Action
Esomeprazole is a proton pump inhibitor that specifically inhibits the H+/K+-ATPase enzyme system (the proton pump) in the gastric parietal cells. This reduces gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly excreted in urine (approximately 80%) and feces (approximately 20%) as metabolites.
Half life
Approximately 1-1.5 hours
Absorption
Rapidly absorbed, peak plasma concentrations reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) system, primarily CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Diazepam
Decreased metabolism of diazepam.
Warfarin
Increased INR and prothrombin time, monitor carefully.
Nelfinavir
Significant decrease in nelfinavir plasma levels, contraindicated.
Clopidogrel
Reduced antiplatelet effect of clopidogrel, use with caution.
Methotrexate
Increased plasma levels of methotrexate, monitor for toxicity.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms are generally mild and include confusion, drowsiness, blurred vision, tachycardia, nausea, sweating, flushing, headache, dry mouth, and other gastrointestinal disturbances. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Excreted in breast milk, use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Diazepam
Decreased metabolism of diazepam.
Warfarin
Increased INR and prothrombin time, monitor carefully.
Nelfinavir
Significant decrease in nelfinavir plasma levels, contraindicated.
Clopidogrel
Reduced antiplatelet effect of clopidogrel, use with caution.
Methotrexate
Increased plasma levels of methotrexate, monitor for toxicity.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms are generally mild and include confusion, drowsiness, blurred vision, tachycardia, nausea, sweating, flushing, headache, dry mouth, and other gastrointestinal disturbances. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Excreted in breast milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Patent expired for generic versions
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials demonstrating efficacy and safety for acid-related disorders.
Lab Monitoring
- Magnesium levels (especially with prolonged use or concurrent diuretics)
- Liver function tests (in patients with severe hepatic impairment)
- INR/PT (for patients on warfarin)
Doctor Notes
- Advise patients on lifestyle modifications.
- Monitor magnesium levels in patients on prolonged therapy.
- Consider drug interactions, especially with clopidogrel and warfarin.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking the medicine suddenly.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose.
Driving Precautions
Esomeprazole is generally not expected to affect the ability to drive or operate machinery. However, if side effects like dizziness or blurred vision occur, avoid such activities.
Lifestyle Advice
- Avoid spicy and fatty foods.
- Limit alcohol and caffeine intake.
- Maintain a healthy weight.
- Avoid lying down immediately after meals.
- Elevate the head of your bed.
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