Etnol
Generic Name
Atenolol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| etnol 100 mg tablet | ৳ 1.38 | ৳ 13.80 |
Description
Overview of the medicine
Etnol-100 mg Tablet contains Atenolol, a beta-blocker primarily used to treat high blood pressure (hypertension), angina (chest pain), and certain heart rhythm disorders. It works by affecting the body's response to some nerve impulses, especially in the heart. This slows down the heart rate, making it pump more efficiently and reducing blood pressure.
Uses & Indications
Dosage
Adults
Hypertension: Initially 50 mg once daily, may be increased to 100 mg once daily after 1-2 weeks. Angina: 50-100 mg once daily. Arrhythmias: 50-100 mg once daily. Myocardial Infarction: 100 mg once daily (after initial IV administration if appropriate).
Elderly
Lower initial doses (e.g., 25 mg once daily) may be appropriate, especially if renal function is impaired. Dose titration should be done carefully.
Renal_impairment
Dosage adjustment is necessary. Creatinine clearance 15-35 mL/min: max 50 mg daily. Creatinine clearance <15 mL/min: max 25 mg daily or 50 mg every other day. Hemodialysis patients: 25-50 mg after each dialysis.
How to Take
Take Etnol-100 mg tablet orally, usually once daily, with or without food. Swallow the tablet whole with water. Do not crush or chew it. Try to take it at the same time each day to maintain a consistent level of medication in your body.
Mechanism of Action
Atenolol is a selective beta-1 adrenergic receptor blocking agent. It primarily acts on beta-1 receptors in the heart, reducing heart rate, cardiac output, and myocardial oxygen demand. It also reduces renin release from the kidneys, which contributes to its antihypertensive effect. Unlike non-selective beta-blockers, it has less effect on beta-2 receptors in the bronchi and peripheral blood vessels, making it generally safer for patients with respiratory conditions.
Pharmacokinetics
Onset
Within 1 hour after oral administration.
Excretion
Primarily excreted unchanged by the kidneys. Approximately 50% of the absorbed dose is excreted in the urine within 24 hours.
Half life
Approximately 6-7 hours in individuals with normal renal function, but can extend significantly in renal impairment.
Absorption
Approximately 50% of an oral dose is absorbed from the gastrointestinal tract. Peak plasma concentrations occur 2-4 hours after ingestion.
Metabolism
Minimal hepatic metabolism; less than 10% is metabolized in the liver.
Side Effects
Contraindications
- •Known hypersensitivity to atenolol or any component of the tablet
- •Sinus bradycardia (slow heart rate)
- •Second or third degree atrioventricular (AV) block
- •Cardiogenic shock
- •Overt cardiac failure (decompensated heart failure)
- •Sick sinus syndrome
- •Untreated pheochromocytoma
- •Metabolic acidosis
- •Severe peripheral arterial circulatory disturbances
Drug Interactions
Digoxin
Increased risk of bradycardia and AV block.
MAO Inhibitors
Increased risk of hypertensive crisis.
Insulin and Oral Hypoglycemics
Atenolol may mask symptoms of hypoglycemia (e.g., tremor, tachycardia).
NSAIDs (e.g., Ibuprofen, Indomethacin)
May reduce the antihypertensive effects of atenolol.
Calcium Channel Blockers (e.g., Verapamil, Diltiazem)
May cause additive effects leading to severe bradycardia, heart block, and hypotension.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe bradycardia, hypotension, acute cardiac failure, bronchospasm, and hypoglycemia. Management includes gastric lavage, activated charcoal, and symptomatic and supportive treatment. Atropine, glucagon, IV fluids, vasopressors, and bronchodilators may be administered as needed.
Pregnancy & Lactation
Pregnancy Category D: Atenolol has been shown to cause fetal harm. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Lactation: Atenolol is excreted in human milk and may cause adverse effects in a breastfed infant (e.g., bradycardia, hypoglycemia). Use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Pharmacies nationwide
Approval Status
Approved by FDA/DGDA
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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