Etrib
Generic Name
Etoricoxib
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| etrib 60 mg tablet | ৳ 7.00 | ৳ 70.00 |
| etrib 90 mg tablet | ৳ 12.04 | ৳ 120.40 |
Description
Overview of the medicine
Etrib (Etoricoxib) is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and gout.
Uses & Indications
Dosage
Adults
Osteoarthritis: 60 mg once daily. Rheumatoid Arthritis, Ankylosing Spondylitis: 90 mg once daily. Acute Gout: 120 mg once daily (max 8 days). Acute Pain/Dysmenorrhea: 120 mg once daily (max 8 days) or 90 mg once daily for up to 3 days for dental surgery pain.
Elderly
No dosage adjustment generally required, but caution is advised due to potential age-related decrease in renal function.
Renal_impairment
Mild to moderate renal impairment (CrCl 30-80 mL/min): No dosage adjustment required. Severe renal impairment (CrCl <30 mL/min): Not recommended.
How to Take
Take orally, with or without food. Swallow the tablet whole with a glass of water.
Mechanism of Action
Etoricoxib selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, which is responsible for the synthesis of prostaglandins, mediators of pain and inflammation. By inhibiting COX-2, it reduces the production of these inflammatory substances.
Pharmacokinetics
Onset
Analgesic effects typically begin within 24 minutes.
Excretion
Primarily excreted via the kidneys (70%) and in feces (20%) as metabolites.
Half life
Approximately 22 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, with an oral bioavailability of approximately 100%. Peak plasma concentrations are reached in about 1 hour.
Metabolism
Extensively metabolized in the liver, primarily via the cytochrome P450 (CYP) isoenzyme CYP3A4, forming inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to etoricoxib or any component of the product
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Congestive heart failure (NYHA II-IV)
- Established ischemic heart disease, peripheral arterial disease, and/or cerebrovascular disease
- Uncontrolled hypertension (blood pressure consistently above 140/90 mmHg)
- Active peptic ulceration or gastrointestinal bleeding
- Severe hepatic dysfunction (Child-Pugh score >9)
- Severe renal dysfunction (CrCl <30 mL/min)
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity
Warfarin
Increased INR and bleeding risk
Rifampicin
Decreased etoricoxib plasma concentrations
Methotrexate
Increased methotrexate plasma levels, increased toxicity
Oral Contraceptives
Increased exposure to ethinyl estradiol, potentially increasing adverse effects
Furosemide/Thiazide diuretics
Reduced natriuretic effect
ACE inhibitors/Angiotensin II Receptor Antagonists
Reduced antihypertensive effect, increased risk of renal impairment
Storage
Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek immediate medical attention. Management is supportive and symptomatic; gastric decontamination (e.g., activated charcoal) may be considered if ingestion is recent.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential for premature closure of the fetal ductus arteriosus. Use with caution during lactation; it is unknown whether etoricoxib is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, depending on storage conditions.
Availability
Pharmacies, hospitals
Approval Status
Approved in many countries
Patent Status
Generics available (patent expired in many regions)
Clinical Trials
Etoricoxib has undergone extensive clinical trials demonstrating its efficacy and safety in various pain and inflammatory conditions. Trials have compared it with other NSAIDs and placebos.
Lab Monitoring
- Blood pressure monitoring (regularly, especially in hypertensive patients)
- Renal function tests (e.g., serum creatinine, BUN) periodically
- Liver function tests (e.g., AST, ALT) periodically
Doctor Notes
- Prescribe the lowest effective dose for the shortest possible duration consistent with individual patient treatment goals.
- Monitor blood pressure regularly, especially at the start of treatment and during dose escalation.
- Exercise caution in patients with a history of cardiovascular disease or risk factors.
- Evaluate gastrointestinal risk factors before prescribing and consider co-administration of gastroprotective agents if needed.
Patient Guidelines
- Take Etrib exactly as prescribed by your doctor.
- Do not exceed the recommended dose or duration of treatment.
- Inform your doctor about any history of heart problems, high blood pressure, stomach ulcers, or kidney disease.
- Report any signs of gastrointestinal bleeding (e.g., black, tarry stools) or cardiovascular events (e.g., chest pain, shortness of breath) immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose.
Driving Precautions
Etoricoxib may cause dizziness or somnolence in some patients. Patients should be cautious when driving or operating machinery until they know how Etrib affects them.
Lifestyle Advice
- Adopt a heart-healthy lifestyle, including a balanced diet and regular exercise.
- Avoid smoking and limit alcohol consumption.
- Manage underlying conditions like high blood pressure and diabetes.
- Discuss any concerns about your medication with your healthcare provider.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.