Etuf
Generic Name
Etodolac
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| etuf 200 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Etodolac is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and stiffness caused by various conditions such as osteoarthritis, rheumatoid arthritis, and other painful conditions. It works by blocking the production of certain natural substances in the body that cause inflammation.
Uses & Indications
Dosage
Adults
For osteoarthritis and rheumatoid arthritis, initially 300 mg two or three times daily, or 400 mg or 500 mg twice daily. Maximum 1200 mg/day. For acute pain, 200-400 mg every 6-8 hours as needed, not exceeding 1200 mg/day.
Elderly
No specific dose adjustment is generally required, but caution is advised due to increased risk of adverse effects. Start with the lowest effective dose.
Renal_impairment
Use with caution. Dosage reduction may be necessary in patients with severe renal impairment. Avoid in severe renal failure.
How to Take
Take Etodolac tablet orally with a full glass of water, preferably with food or milk to minimize gastrointestinal upset. Do not crush, chew, or break the tablet. Follow your doctor's instructions regarding dose and duration.
Mechanism of Action
Etodolac primarily acts as a non-selective inhibitor of cyclooxygenase (COX-1 and COX-2) enzymes. This inhibition reduces the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever. While it primarily targets COX-2, it also inhibits COX-1, leading to its anti-inflammatory, analgesic, and antipyretic effects.
Pharmacokinetics
Onset
Within 30-60 minutes for analgesia; several days for anti-inflammatory effects.
Excretion
Mainly excreted in urine (approximately 75%) as metabolites, with a small amount (approximately 10%) excreted in feces.
Half life
Approximately 6-7 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract; peak plasma concentrations achieved in 1-2 hours.
Metabolism
Extensively metabolized in the liver, primarily via hydroxylation and glucuronidation.
Side Effects
Contraindications
- Known hypersensitivity to etodolac, aspirin, or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Coronary artery bypass graft (CABG) surgery (peri-operative pain)
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
Diuretics and ACE inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, lethargy. More severe effects can include gastrointestinal bleeding, acute renal failure, and respiratory depression. Treatment is symptomatic and supportive; there is no specific antidote. Gastric lavage and activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters); avoid in third trimester (Category D) due to potential for premature closure of ductus arteriosus and other risks. Consult a doctor. Not recommended during breastfeeding as it may pass into breast milk; use with caution or consider alternatives.
Side Effects
Contraindications
- Known hypersensitivity to etodolac, aspirin, or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Coronary artery bypass graft (CABG) surgery (peri-operative pain)
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
Diuretics and ACE inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, lethargy. More severe effects can include gastrointestinal bleeding, acute renal failure, and respiratory depression. Treatment is symptomatic and supportive; there is no specific antidote. Gastric lavage and activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters); avoid in third trimester (Category D) due to potential for premature closure of ductus arteriosus and other risks. Consult a doctor. Not recommended during breastfeeding as it may pass into breast milk; use with caution or consider alternatives.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Numerous clinical trials have demonstrated Etodolac's efficacy and safety in managing pain and inflammation in conditions like osteoarthritis and rheumatoid arthritis. Studies typically compare Etodolac to placebo or other NSAIDs, showing comparable efficacy with a generally favorable safety profile when used appropriately.
Lab Monitoring
- Complete Blood Count (CBC) (for long-term therapy)
- Renal function tests (e.g., serum creatinine, BUN)
- Liver function tests (e.g., AST, ALT)
- Stool for occult blood (for long-term therapy)
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Monitor patients for signs and symptoms of GI bleeding, cardiovascular events, and renal toxicity, especially with prolonged use.
- Assess patient's cardiovascular and GI risk factors before initiating therapy.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose or duration of treatment.
- Take with food or milk to reduce stomach upset.
- Report any unusual bleeding, persistent stomach pain, dark stools, or yellowing of the skin/eyes to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Etodolac may cause dizziness, drowsiness, or blurred vision in some individuals. If you experience these effects, avoid driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Avoid alcohol consumption while taking this medicine, as it may increase the risk of stomach bleeding.
- Maintain a healthy lifestyle, including a balanced diet and regular exercise, as recommended by your doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.