Eusef-DS
Generic Name
Cefixime 250 mg/5 ml Suspension
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| eusef ds 250 mg suspension | ৳ 140.00 | N/A |
Description
Overview of the medicine
Eusef-DS 250 mg Suspension contains Cefixime, a third-generation cephalosporin antibiotic. It is used to treat a wide range of bacterial infections including those of the respiratory tract, urinary tract, ear, nose, throat, and skin.
Uses & Indications
Dosage
Adults
For children (typically 6 months to 12 years): 8 mg/kg body weight daily, administered as a single dose or in two divided doses. For 250 mg/5 ml suspension, this would be e.g., 5 ml (250 mg) for a 30kg child. Max. 400 mg/day. (Adult dosage if used: 400 mg once daily).
Elderly
No specific dosage adjustment required in the elderly unless there is severe renal impairment. Renal function should be monitored.
Renal_impairment
In patients with creatinine clearance < 60 mL/min, the dose should be reduced. For CrCl 21-60 mL/min, 75% of standard dose. For CrCl < 20 mL/min, 50% of standard dose.
How to Take
Administer orally, with or without food. Shake the suspension well before each use. Use an accurate measuring device provided with the medicine.
Mechanism of Action
Cefixime acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby inhibiting the third and final stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefixime interferes with an autolysin inhibitor.
Pharmacokinetics
Onset
Peak plasma concentration reached within 2-6 hours.
Excretion
Excreted primarily in the urine (about 50% unchanged) and to a lesser extent in bile.
Half life
Elimination half-life is typically 3-4 hours.
Absorption
About 40-50% orally absorbed. Food may delay time to peak concentration but the total absorbed amount remains unchanged.
Metabolism
Cefixime is not extensively metabolized in the liver; limited metabolism occurs.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics
- History of serious hypersensitivity reactions to penicillin or other beta-lactam antibiotics
Drug Interactions
Warfarin
May increase prothrombin time, monitor INR.
Probenecid
Increases cefixime plasma levels by decreasing renal excretion.
Carbamazepine
Increased carbamazepine levels reported with concomitant use.
Storage
Store dry powder below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children. After reconstitution, store in a refrigerator (2-8°C) and discard any unused portion after 7 days.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics
- History of serious hypersensitivity reactions to penicillin or other beta-lactam antibiotics
Drug Interactions
Warfarin
May increase prothrombin time, monitor INR.
Probenecid
Increases cefixime plasma levels by decreasing renal excretion.
Carbamazepine
Increased carbamazepine levels reported with concomitant use.
Storage
Store dry powder below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children. After reconstitution, store in a refrigerator (2-8°C) and discard any unused portion after 7 days.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
As dry powder: 24-36 months. After reconstitution: 7 days when stored in a refrigerator (2-8°C).
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Cefixime has been evaluated in numerous clinical trials demonstrating its efficacy and safety across various bacterial infections in both adult and pediatric populations.
Lab Monitoring
- Renal function tests (for prolonged therapy or in patients with pre-existing renal impairment)
- Hepatic function tests (for prolonged therapy)
- Complete blood count (CBC) (for prolonged therapy)
Doctor Notes
- Counsel patients on the importance of completing the full course of therapy to prevent antibiotic resistance.
- Consider renal function adjustment in patients with impaired kidney function.
- Be aware of potential for C. difficile-associated diarrhea, even weeks after discontinuation.
Patient Guidelines
- Take the full course of medicine as prescribed, even if you feel better.
- Do not stop taking this medicine without consulting your doctor.
- Do not share this medicine with others, even if they have similar symptoms.
- Shake the suspension well before each use.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Cefixime generally does not impair the ability to drive or operate machinery. However, if you experience dizziness or headache, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Ensure adequate rest to aid recovery.
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