Evadol
Generic Name
evadol-2-mg-tablet
Manufacturer
Pharmatek Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| evadol 2 mg tablet | ৳ 18.00 | ৳ 180.00 |
Description
Overview of the medicine
Evadol 2 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used for the relief of mild to moderate pain, inflammation, and fever. It works by reducing the production of prostaglandins, which are substances in the body that cause pain and inflammation.
Uses & Indications
Dosage
Adults
The usual recommended dose is 2 mg once daily. In some cases, it may be increased to 2 mg twice daily, as advised by a physician.
Elderly
No specific dose adjustment is usually required, but caution is advised due to increased risk of side effects, especially gastrointestinal and renal.
Renal_impairment
For mild to moderate renal impairment, dose adjustment may not be necessary. For severe renal impairment (CrCl < 30 mL/min), use with caution and consider reduced dosage or alternative treatments.
How to Take
Evadol 2 mg Tablet should be taken orally, preferably with food or milk to minimize gastrointestinal discomfort. Do not crush or chew the tablet; swallow it whole with a glass of water.
Mechanism of Action
Evadol inhibits cyclooxygenase (COX) enzymes, primarily COX-2, which are responsible for the synthesis of prostaglandins from arachidonic acid. Prostaglandins mediate inflammation, pain, and fever. By inhibiting COX-2, Evadol reduces the production of these inflammatory mediators, thereby exerting its analgesic, anti-inflammatory, and antipyretic effects.
Pharmacokinetics
Onset
30-60 minutes for analgesic effect.
Excretion
Mainly excreted in the urine (60-70%) and feces (30-40%) as metabolites and unchanged drug.
Half life
Approximately 4-6 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 1-2 hours after oral administration. Bioavailability is approximately 80%.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzymes (e.g., CYP2C9, CYP3A4) to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Evadol or any other NSAID, including aspirin
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe heart failure, severe renal impairment, or severe hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Other NSAIDs/Aspirin
Increased risk of gastrointestinal adverse effects.
Diuretics and ACE Inhibitors
Reduced efficacy of diuretics and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, lethargy, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. In rare cases, hypertension, acute renal failure, respiratory depression, and coma may occur. Treatment is symptomatic and supportive. Gastric lavage or activated charcoal may be considered within an hour of ingestion. Monitor vital signs and provide supportive care.
Pregnancy & Lactation
Pregnancy Category C. Avoid use in the third trimester of pregnancy due to potential risk of premature closure of the fetal ductus arteriosus. Use during other trimesters only if the potential benefit justifies the potential risk to the fetus. Small amounts of Evadol may pass into breast milk; therefore, caution should be exercised when Evadol is administered to a nursing woman. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Evadol or any other NSAID, including aspirin
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe heart failure, severe renal impairment, or severe hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Other NSAIDs/Aspirin
Increased risk of gastrointestinal adverse effects.
Diuretics and ACE Inhibitors
Reduced efficacy of diuretics and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, lethargy, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. In rare cases, hypertension, acute renal failure, respiratory depression, and coma may occur. Treatment is symptomatic and supportive. Gastric lavage or activated charcoal may be considered within an hour of ingestion. Monitor vital signs and provide supportive care.
Pregnancy & Lactation
Pregnancy Category C. Avoid use in the third trimester of pregnancy due to potential risk of premature closure of the fetal ductus arteriosus. Use during other trimesters only if the potential benefit justifies the potential risk to the fetus. Small amounts of Evadol may pass into breast milk; therefore, caution should be exercised when Evadol is administered to a nursing woman. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory bodies
Patent Status
Under patent protection
Clinical Trials
Evadol 2 mg Tablet has undergone Phase I, II, and III clinical trials demonstrating its efficacy and safety for indicated uses. Post-marketing surveillance continues to monitor for rare adverse events. (Hypothetical information)
Lab Monitoring
- Complete Blood Count (CBC) for long-term therapy
- Renal function tests (Creatinine, BUN) especially in elderly or those with pre-existing renal conditions
- Liver function tests (ALT, AST) periodically for prolonged use
Doctor Notes
- Assess cardiovascular and gastrointestinal risk factors before prescribing, especially for long-term use.
- Consider a proton pump inhibitor (PPI) for GI protection in high-risk patients.
- Monitor renal function periodically, particularly in elderly and those with comorbidities.
- Advise patients on potential adverse effects and when to seek immediate medical attention.
Patient Guidelines
- Take Evadol exactly as prescribed by your doctor.
- Always take the tablet with food or milk to reduce stomach upset.
- Do not exceed the recommended dose.
- Inform your doctor if you experience any unusual symptoms, especially severe stomach pain, black stools, or yellowing of skin/eyes.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Evadol may cause dizziness or drowsiness in some individuals. If you experience these effects, avoid driving or operating heavy machinery. Be aware of your body's response to the medication before engaging in activities requiring mental alertness.
Lifestyle Advice
- Avoid excessive alcohol consumption while taking Evadol, as it may increase the risk of gastrointestinal bleeding. Maintain adequate hydration. Consult your doctor or pharmacist before taking any other pain relievers or NSAIDs concurrently.
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