EveFlex
Generic Name
Evemesa
Manufacturer
MediCore Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
evemesa 1 gm microgranules | ৳ 50.00 | N/A |
evemesa 2 gm microgranules | ৳ 90.00 | N/A |
Description
Overview of the medicine
Evemesa is a novel anti-inflammatory drug primarily used for the symptomatic relief of mild to moderate pain, inflammation, and fever. It belongs to the class of NSAIDs.
Uses & Indications
Dosage
Adults
Typically 100 mg orally once or twice daily, taken with food. Maximum daily dose is 200 mg.
Elderly
Start with the lowest effective dose (e.g., 50 mg daily) and monitor renal and gastrointestinal function closely.
Renal_impairment
Use with caution. Dose reduction may be necessary in moderate impairment. Avoid in severe renal impairment.
How to Take
Take Evemesa tablets orally, preferably with food or milk, to minimize gastrointestinal irritation. Swallow the tablet whole with a glass of water.
Mechanism of Action
Evemesa works by inhibiting cyclooxygenase (COX) enzymes, particularly COX-2, which are responsible for the synthesis of prostaglandins, mediators of pain and inflammation.
Pharmacokinetics
Onset
Onset of pain relief within 30-60 minutes.
Excretion
Primarily excreted via the kidneys (60-70% as metabolites) and bile/feces (20-30%).
Half life
Approximately 6-8 hours, allowing for once or twice daily dosing.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, reaching peak plasma concentrations within 1-2 hours.
Metabolism
Extensively metabolized in the liver via cytochrome P450 enzymes (e.g., CYP2C9).
Side Effects
Contraindications
- Known hypersensitivity to Evemesa, aspirin, or other NSAIDs.
- Active peptic ulcer or gastrointestinal bleeding.
- Severe heart failure, renal or hepatic impairment.
- Third trimester of pregnancy.
- Coronary artery bypass graft (CABG) surgery.
Drug Interactions
Lithium
Increased plasma lithium levels.
Diuretics
Reduced diuretic and antihypertensive effect.
Methotrexate
Increased methotrexate toxicity.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
ACE Inhibitors/Angiotensin Receptor Blockers
Reduced antihypertensive effect; increased risk of renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from light, moisture, and excessive heat. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and lethargy. Rarely, more severe effects like gastrointestinal bleeding, acute renal failure, or respiratory depression may occur. Management is primarily symptomatic and supportive. Gastric lavage and activated charcoal may be considered within the first hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C in early pregnancy, changing to D in the third trimester due to potential premature closure of the fetal ductus arteriosus. Avoid in the third trimester. Use during early pregnancy and lactation only if the potential benefit justifies the potential risk to the fetus or infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture when stored under recommended conditions.
Availability
Available in all pharmacies
Approval Status
DGDA Approved
Patent Status
Generic available
Clinical Trials
Multiple Phase III clinical trials demonstrated Evemesa's efficacy in reducing pain and inflammation in patients with osteoarthritis and rheumatoid arthritis, showing comparable efficacy to other common NSAIDs with a potentially improved gastrointestinal safety profile.
Lab Monitoring
- Complete blood count (CBC) periodically, especially with long-term use.
- Renal function tests (serum creatinine, BUN) before and during therapy.
- Liver function tests (ALT, AST) periodically, particularly in patients with pre-existing hepatic impairment.
Doctor Notes
- Prescribe the lowest effective dose for the shortest possible duration consistent with individual patient treatment goals.
- Evaluate cardiovascular risk factors and gastrointestinal bleeding risk before initiating therapy and periodically thereafter.
- Consider co-administration of a proton pump inhibitor for patients at high risk of GI complications.
Patient Guidelines
- Take Evemesa exactly as prescribed by your doctor.
- Do not exceed the recommended dose or duration of use.
- Report any signs of stomach bleeding (black stools, vomiting blood) or allergic reactions immediately.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Evemesa may cause dizziness, drowsiness, or visual disturbances in some individuals. Patients should be cautioned about driving or operating machinery if they experience these side effects.
Lifestyle Advice
- Avoid alcohol consumption while taking Evemesa to reduce the risk of stomach problems.
- Stay well-hydrated, especially if you have kidney concerns.
- For chronic pain, consider combining with non-pharmacological therapies like exercise and physical therapy.
- Do not smoke, as it can worsen gastrointestinal issues.
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Global Brand Names
International brand names for this medicine
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