Take Evemesa tablets orally, preferably with food or milk, to minimize gastrointestinal irritation. Swallow the tablet whole with a glass of water.

Evemesa works by inhibiting cyclooxygenase (COX) enzymes, particularly COX-2, which are responsible for the synthesis of prostaglandins, mediators of pain and inflammation.

• •Known hypersensitivity to Evemesa, aspirin, or other NSAIDs.
• •Active peptic ulcer or gastrointestinal bleeding.
• •Severe heart failure, renal or hepatic impairment.
• •Third trimester of pregnancy.
• •Coronary artery bypass graft (CABG) surgery.

Store in a cool, dry place, below 30°C. Protect from light, moisture, and excessive heat. Keep out of reach of children.

Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and lethargy. Rarely, more severe effects like gastrointestinal bleeding, acute renal failure, or respiratory depression may occur. Management is primarily symptomatic and supportive. Gastric lavage and activated charcoal may be considered within the first hour of ingestion.

Pregnancy Category C in early pregnancy, changing to D in the third trimester due to potential premature closure of the fetal ductus arteriosus. Avoid in the third trimester. Use during early pregnancy and lactation only if the potential benefit justifies the potential risk to the fetus or infant.