Oral administration. The microgranules can be taken with or without food. They should be poured onto the tongue and swallowed whole with water or mixed with yogurt or apple sauce, immediately consuming the mixture. Do not chew or crush the microgranules.

Mesalazine is a 5-aminosalicylate (5-ASA) that acts locally in the bowel. Its exact mechanism is not fully understood but is thought to involve inhibition of prostaglandin and leukotriene synthesis, scavenging free radicals, and modulation of immune responses, thereby reducing inflammation in the gastrointestinal tract.

• •Hypersensitivity to mesalazine or salicylates
• •Severe renal or hepatic impairment
• •Gastric or duodenal ulcer

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Symptoms: Nausea, vomiting, abdominal pain, drowsiness, dizziness, headache. Management: Symptomatic and supportive care. Gastric lavage or activated charcoal may be considered if recent ingestion. Monitor renal and hepatic function.

Use during pregnancy only if clearly needed and potential benefits outweigh risks. Mesalazine crosses the placenta. Excreted in breast milk, use with caution during lactation; monitor infant for diarrhea.