Exmart
Generic Name
exmart-20-mg-tablet
Manufacturer
MediCorp Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| exmart 20 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Exmart 20 mg tablet contains Escitalopram, a selective serotonin reuptake inhibitor (SSRI) used to treat major depressive disorder, generalized anxiety disorder, panic disorder, social anxiety disorder, and obsessive-compulsive disorder.
Uses & Indications
Dosage
Adults
Initial dose 10 mg once daily, may be increased to 20 mg once daily after at least one week based on response. Maximum recommended dose is 20 mg/day.
Elderly
A lower initial dose of 5 mg once daily may be considered, with careful titration up to a maximum of 10 mg once daily.
Renal_impairment
No dosage adjustment needed for mild to moderate impairment. Use with caution in severe renal impairment (creatinine clearance <20 mL/min).
How to Take
Take orally once daily, with or without food. Swallow the tablet whole with water.
Mechanism of Action
Escitalopram selectively inhibits the reuptake of serotonin (5-HT) in the central nervous system, thereby enhancing and prolonging the effects of serotonin in the brain. This action is thought to be responsible for its antidepressant and anxiolytic effects.
Pharmacokinetics
Onset
Initial therapeutic effects may be seen within 2-4 weeks, with full effect in 4-6 weeks.
Excretion
Excreted through urine (primarily) and feces as metabolites.
Half life
Approximately 27-32 hours, allowing for once-daily dosing.
Absorption
Well absorbed orally, independent of food. Peak plasma concentrations are reached in approximately 4-5 hours.
Metabolism
Extensively metabolized in the liver by CYP3A4, CYP2C19, and CYP2D6 to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Escitalopram or any component of the formulation.
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of stopping MAOI treatment.
- Concomitant use with Pimozide.
- Congenital long QT syndrome or acquired long QT interval.
Drug Interactions
Pimozide
Concomitant use is contraindicated due to increased QT prolongation risk.
Metoprolol
May increase Metoprolol plasma levels, adjust Metoprolol dose if needed.
Warfarin and other anticoagulants
Increased risk of bleeding due to effects on platelet aggregation.
MAOIs (e.g., Phenelzine, Selegiline)
Risk of serious, sometimes fatal, reactions including serotonin syndrome.
NSAIDs (e.g., Ibuprofen) and Aspirin
Increased risk of gastrointestinal bleeding.
Other serotonergic drugs (e.g., Triptans, Tramadol, St. John's Wort)
Increased risk of serotonin syndrome.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dizziness, tremor, agitation, somnolence, nausea, vomiting, sinus tachycardia, and in rare cases, serotonin syndrome. Treatment is supportive and symptomatic; ensure airway patency, monitor cardiac rhythm and vital signs. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Neonates exposed to SSRIs late in the third trimester have developed complications. Excreted into breast milk; caution advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from the date of manufacture, depending on storage conditions.
Availability
Available in pharmacies, hospitals, and clinics
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA for generic equivalent)
Patent Status
Generic versions widely available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Escitalopram in the treatment of various anxiety and depressive disorders. Studies consistently show superior efficacy compared to placebo and comparable efficacy to other SSRIs, with a generally favorable tolerability profile.
Lab Monitoring
- No routine lab monitoring is generally required.
- Monitor serum sodium levels, especially in elderly patients or those taking diuretics, due to risk of hyponatremia.
- Liver function tests may be considered in patients with pre-existing hepatic impairment.
Doctor Notes
- Emphasize the importance of adherence to treatment and gradual tapering when discontinuing.
- Screen for bipolar disorder before initiating treatment to avoid precipitation of mania/hypomania.
- Monitor for emergent suicidality, especially during initial therapy or dose adjustments.
Patient Guidelines
- Take exactly as prescribed by your doctor. Do not stop taking it suddenly, as this can cause withdrawal symptoms.
- It may take several weeks for the full antidepressant effect to be felt.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Be aware of the increased risk of suicidal thoughts, especially at the beginning of treatment or after a dose change.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Exmart may cause dizziness, drowsiness, or impaired judgment. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Avoid alcohol consumption while taking Exmart, as it may enhance adverse effects.
- Engage in regular physical activity and maintain a balanced diet as part of an overall mental health strategy.
- Practice stress-reduction techniques such as mindfulness or meditation.
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Global Brand Names
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