Ezepain
Generic Name
Ezetin 120 mg Tablet
Manufacturer
Ezecare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ezepain 120 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Ezepain 120 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used for the relief of mild to moderate pain, inflammation, and fever.
Uses & Indications
Dosage
Adults
The usual adult dose is 120 mg to 240 mg taken once or twice daily, preferably with food. Do not exceed 480 mg in 24 hours.
Elderly
Lower doses may be required. Start with 120 mg once daily and adjust according to response and tolerability.
Renal_impairment
Use with caution. Dosage reduction may be necessary. Not recommended for severe renal impairment.
How to Take
Take Ezepain 120 mg Tablet orally with a full glass of water, preferably with food or milk to minimize gastrointestinal upset.
Mechanism of Action
Ezepain (Ezetin) inhibits cyclooxygenase (COX) enzymes, primarily COX-1 and COX-2, which are responsible for the synthesis of prostaglandins. Prostaglandins mediate pain, inflammation, and fever. By inhibiting their synthesis, Ezetin reduces these symptoms.
Pharmacokinetics
Onset
Pain relief usually begins within 30-60 minutes.
Excretion
Mainly excreted in the urine as metabolites and conjugates, with a small portion excreted in the feces.
Half life
Approximately 2-4 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are usually reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver via cytochrome P450 enzymes into inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Ezetin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe renal or hepatic impairment
- Last trimester of pregnancy
- Patients with asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Methotrexate
Increased methotrexate toxicity.
Other NSAIDs or Aspirin
Increased risk of gastrointestinal adverse effects.
Diuretics and ACE Inhibitors
Reduced hypotensive effects and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, drowsiness, dizziness, and headache. Severe overdose may lead to renal failure, respiratory depression, and coma. Management is symptomatic and supportive; there is no specific antidote. Gastric lavage or activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential fetal harm (e.g., premature closure of the ductus arteriosus). Use with caution during the first and second trimesters and during lactation only if clearly needed and the benefit outweighs the risk.
Side Effects
Contraindications
- Hypersensitivity to Ezetin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe renal or hepatic impairment
- Last trimester of pregnancy
- Patients with asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Methotrexate
Increased methotrexate toxicity.
Other NSAIDs or Aspirin
Increased risk of gastrointestinal adverse effects.
Diuretics and ACE Inhibitors
Reduced hypotensive effects and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, drowsiness, dizziness, and headache. Severe overdose may lead to renal failure, respiratory depression, and coma. Management is symptomatic and supportive; there is no specific antidote. Gastric lavage or activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential fetal harm (e.g., premature closure of the ductus arteriosus). Use with caution during the first and second trimesters and during lactation only if clearly needed and the benefit outweighs the risk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA
Patent Status
Patented
Clinical Trials
Clinical trials demonstrated significant efficacy in pain relief and inflammation reduction, with a favorable safety profile compared to placebo. Ongoing post-marketing surveillance continues to monitor long-term effects.
Lab Monitoring
- Periodic monitoring of renal function (serum creatinine, BUN) and complete blood count (CBC) is recommended during long-term therapy.
Doctor Notes
- Prescribe the lowest effective dose for the shortest possible duration.
- Assess cardiovascular and gastrointestinal risk factors before initiating therapy.
- Monitor renal function, blood pressure, and CBC periodically, especially in elderly patients or those with pre-existing conditions.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not exceed the recommended dose or duration of treatment.
- Take with food or milk to reduce stomach upset.
- Report any unusual bleeding, severe stomach pain, or black stools to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause dizziness or drowsiness in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption while taking this medication as it may increase the risk of stomach bleeding.
- Maintain adequate hydration.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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