Ezevent
Generic Name
Ezetimibe
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ezevent 10 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Ezevent is a medication used to lower high cholesterol levels in the blood. It works by inhibiting the absorption of cholesterol in the small intestine, thereby reducing the amount of cholesterol available to the liver, which leads to a reduction in LDL ('bad') cholesterol.
Uses & Indications
Dosage
Adults
The recommended dose is 10 mg once daily, taken with or without food.
Elderly
No dose adjustment is required for elderly patients.
Renal_impairment
No dose adjustment is necessary for patients with mild to moderate renal impairment. Caution is advised in severe renal impairment (CrCl <30 mL/min).
How to Take
Ezevent should be taken orally once daily, with or without food. It can be taken at any time of day.
Mechanism of Action
Ezetimibe selectively inhibits the absorption of dietary and biliary cholesterol by the small intestine, without affecting the absorption of fat-soluble vitamins, triglycerides, or bile acids. It binds to the Niemann-Pick C1-like 1 (NPC1L1) protein, which is crucial for cholesterol uptake.
Pharmacokinetics
Onset
Lipid-lowering effects are observed within 2 weeks.
Excretion
Mainly excreted in the feces (approximately 78%) and to a lesser extent in the urine (approximately 11%).
Half life
Approximately 22 hours for both ezetimibe and its active metabolite.
Absorption
Ezetimibe is rapidly absorbed and extensively metabolized to its active phenolic glucuronide form (ezetimibe-glucuronide) in the small intestine and liver.
Metabolism
Primarily in the small intestine and liver via glucuronide conjugation (Phase II reaction).
Side Effects
Contraindications
- Hypersensitivity to the active substance or to any of the excipients.
- When Ezevent is co-administered with a statin, the combination is contraindicated in patients with active liver disease or unexplained persistent elevations in serum transaminases.
Drug Interactions
Statins
Increased risk of myopathy/rhabdomyolysis when co-administered with statins.
Fibrates
Coadministration with fibrates (especially gemfibrozil) increases the risk of cholelithiasis and cholecystitis. Not recommended with gemfibrozil.
Cyclosporine
Concomitant administration with cyclosporine may increase ezetimibe concentrations. Monitor cyclosporine levels.
Cholestyramine
May decrease the absorption of ezetimibe. Take Ezevent at least 2 hours before or 4 hours after cholestyramine.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, symptomatic and supportive measures should be taken. No specific antidote is available.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether ezetimibe is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, check product packaging for exact date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Generic versions available, original patent expired
Clinical Trials
IMPROVE-IT trial demonstrated that combination therapy with ezetimibe and simvastatin significantly reduced cardiovascular events compared to simvastatin monotherapy.
Lab Monitoring
- Lipid profile (total cholesterol, LDL-C, HDL-C, triglycerides) should be monitored periodically.
- Liver function tests (ALT, AST) should be performed before initiating therapy and periodically thereafter, especially if co-administered with a statin.
Doctor Notes
- Consider Ezevent for patients who require additional LDL-C lowering despite statin therapy.
- Useful for statin-intolerant patients or those with contraindications to statins.
Patient Guidelines
- Take Ezevent exactly as prescribed by your doctor.
- Continue to follow your cholesterol-lowering diet and exercise program.
- Inform your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Ezevent is not expected to affect the ability to drive or operate machinery. However, patients should be aware of rare side effects like dizziness.
Lifestyle Advice
- Maintain a heart-healthy diet low in saturated and trans fats.
- Engage in regular physical activity.
- Avoid smoking and excessive alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.