Eziflo
Generic Name
Tamsulosin Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| eziflo 04 mg capsule | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Tamsulosin is an alpha-adrenergic blocker used to treat symptoms of benign prostatic hyperplasia (BPH). It relaxes muscles in the prostate and bladder neck, making it easier to urinate.
Uses & Indications
Dosage
Adults
0.4 mg orally once daily, approximately 30 minutes after the same meal each day. May be increased to 0.8 mg once daily after 2-4 weeks if needed.
Elderly
No dosage adjustment required.
Renal_impairment
No dosage adjustment required for mild to moderate impairment. Use with caution in severe impairment.
How to Take
Oral, once daily, approximately 30 minutes after the same meal each day. Swallow the capsule whole; do not crush, chew, or open.
Mechanism of Action
Tamsulosin selectively blocks alpha-1A and alpha-1D adrenergic receptors located in the prostate, prostatic capsule, bladder neck, and prostatic urethra. This blockade causes relaxation of the smooth muscles in these tissues, reducing bladder outflow obstruction.
Pharmacokinetics
Onset
4-8 hours for symptomatic relief.
Excretion
Primarily in urine (76%) and feces (21%).
Half life
Approximately 9-15 hours.
Absorption
Rapidly absorbed after oral administration, bioavailability is nearly 100%.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4 and CYP2D6.
Side Effects
Contraindications
- •Hypersensitivity to tamsulosin or any component of the formulation.
- •History of orthostatic hypotension.
- •Severe hepatic impairment.
Drug Interactions
Other alpha-blockers
Increased risk of hypotension.
Strong CYP2D6 inhibitors (e.g., paroxetine)
May increase tamsulosin exposure.
PDE5 inhibitors (e.g., sildenafil, tadalafil)
May cause additive hypotensive effects.
Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
May significantly increase tamsulosin exposure.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include severe hypotension and compensatory tachycardia. Treatment is supportive, focusing on maintaining cardiovascular stability.
Pregnancy & Lactation
Tamsulosin is not indicated for use in women.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Expired
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Global Brand Names
International brand names for this medicine
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