Ezykof-Plus
Generic Name
Ambroxol Hydrochloride + Guaifenesin
Manufacturer
PharmaCare Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ezykof plus 100 mg syrup | ৳ 80.00 | N/A |
Description
Overview of the medicine
Ezykof-Plus 100 mg Syrup is indicated for the relief of productive cough and respiratory congestion associated with various broncho-pulmonary disorders. It combines a mucolytic agent (Ambroxol) with an expectorant (Guaifenesin) to help thin mucus and facilitate its clearance from the airways.
Uses & Indications
Dosage
Adults
10 ml (2 teaspoonfuls) 2 to 3 times daily, or as directed by the physician.
Elderly
Same as adult dose, with caution. Dose adjustment may be necessary based on renal/hepatic function.
Renal_impairment
Dose intervals should be extended or dosage reduced in severe renal impairment. Consult physician.
How to Take
Administer orally, with or without food. Use a measuring spoon or cup for accurate dosing.
Mechanism of Action
Ambroxol acts as a mucolytic by depolymerizing mucopolysaccharides, thereby liquefying and reducing the viscosity of sputum. Guaifenesin works as an expectorant by increasing the volume and decreasing the viscosity of secretions in the trachea and bronchi, thereby facilitating the removal of phlegm.
Pharmacokinetics
Onset
Ambroxol: Onset of action within 30 minutes. Guaifenesin: Onset within 30 minutes.
Excretion
Ambroxol and its metabolites are primarily excreted renally. Guaifenesin and its metabolites are also excreted renally.
Half life
Ambroxol: Terminal half-life 7-12 hours. Guaifenesin: Half-life approximately 1 hour.
Absorption
Both Ambroxol and Guaifenesin are well absorbed orally. Ambroxol has an absolute bioavailability of about 70-80%. Guaifenesin is rapidly absorbed.
Metabolism
Ambroxol undergoes extensive first-pass metabolism in the liver. Guaifenesin is rapidly metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Ambroxol, Guaifenesin, or any other component of the syrup.
- Severe hepatic or renal impairment (use with caution and dose adjustment).
Drug Interactions
Antitussives
Concomitant use with antitussives (cough suppressants) is not recommended as it may impede the expectoration of liquefied mucus.
Antibiotics (e.g., amoxicillin, cefuroxime)
Ambroxol may increase the penetration of certain antibiotics (like amoxicillin, cefuroxime, erythromycin) into bronchial secretions.
Storage
Store below 30°C, in a dry place. Protect from light and moisture. Do not freeze.
Overdose
Symptoms of overdose may include gastrointestinal disturbances such as nausea, vomiting, diarrhea, and abdominal pain. Management involves symptomatic and supportive treatment. Induce emesis or perform gastric lavage if overdose is recent.
Pregnancy & Lactation
Pregnancy Category C. Use with caution during pregnancy only if the potential benefit outweighs the potential risk to the fetus. It is advisable to consult a doctor before use during lactation, as components may pass into breast milk.
Side Effects
Contraindications
- Hypersensitivity to Ambroxol, Guaifenesin, or any other component of the syrup.
- Severe hepatic or renal impairment (use with caution and dose adjustment).
Drug Interactions
Antitussives
Concomitant use with antitussives (cough suppressants) is not recommended as it may impede the expectoration of liquefied mucus.
Antibiotics (e.g., amoxicillin, cefuroxime)
Ambroxol may increase the penetration of certain antibiotics (like amoxicillin, cefuroxime, erythromycin) into bronchial secretions.
Storage
Store below 30°C, in a dry place. Protect from light and moisture. Do not freeze.
Overdose
Symptoms of overdose may include gastrointestinal disturbances such as nausea, vomiting, diarrhea, and abdominal pain. Management involves symptomatic and supportive treatment. Induce emesis or perform gastric lavage if overdose is recent.
Pregnancy & Lactation
Pregnancy Category C. Use with caution during pregnancy only if the potential benefit outweighs the potential risk to the fetus. It is advisable to consult a doctor before use during lactation, as components may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture when stored correctly.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent
Clinical Trials
While specific clinical trials for Ezykof-Plus 100 mg Syrup may not be publicly available, the active ingredients (Ambroxol and Guaifenesin) have been extensively studied in various clinical trials demonstrating their efficacy and safety in treating cough and respiratory conditions.
Lab Monitoring
- Routine laboratory monitoring is generally not required for this medication.
- Monitor for signs of hypersensitivity reactions.
Doctor Notes
- Effective for productive cough with thick, tenacious mucus.
- Advise patients on adequate hydration to maximize therapeutic effect.
- Rule out underlying infections if cough persists or worsens.
Patient Guidelines
- Follow the prescribed dosage and duration of treatment.
- Do not exceed the recommended dose without consulting a doctor.
- Keep out of reach of children.
- Consult a doctor if symptoms persist or worsen after 7 days.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Ezykof-Plus 100 mg Syrup is generally not known to cause drowsiness or impair driving ability. However, if you experience any dizziness or other side effects that affect your concentration, avoid driving or operating machinery.
Lifestyle Advice
- Drink plenty of fluids (water, juices) to help thin mucus and aid expectoration.
- Avoid smoking and exposure to respiratory irritants, as they can worsen cough.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.