Fap-Plus
Generic Name
Fapicitin Hydrochloride
Manufacturer
MediCare Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fap plus 500 mg tablet | ৳ 1.92 | ৳ 19.20 |
Description
Overview of the medicine
Fap-Plus 500 mg Tablet is a potent analgesic and anti-inflammatory medication used for relief from various types of pain and inflammation.
Uses & Indications
Dosage
Adults
One tablet (500 mg) every 8-12 hours as needed, not exceeding 3 tablets (1500 mg) in 24 hours.
Elderly
A reduced dose may be necessary; consult a physician. Typically, one tablet (500 mg) once daily initially.
Renal_impairment
Use with caution; dose adjustment required for severe impairment. Not recommended for eGFR <30 mL/min.
How to Take
Take orally with a glass of water, preferably after meals to minimize gastrointestinal upset. Do not crush or chew the tablet.
Mechanism of Action
Fapicitin Hydrochloride works by inhibiting specific cyclooxygenase (COX) enzymes, primarily COX-2, leading to reduced prostaglandin synthesis, thereby exerting its analgesic, antipyretic, and anti-inflammatory effects. It also has a central pain modulation effect.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Mainly excreted via urine (60-70%) and feces (20-30%) as metabolites and some unchanged drug.
Half life
3-5 hours
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 80-90%.
Metabolism
Primarily metabolized in the liver via CYP450 enzymes (e.g., CYP2C9 and CYP3A4) into inactive metabolites.
Side Effects
Contraindications
- Known hypersensitivity to Fapicitin or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Severe heart failure
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects, increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, abdominal pain, drowsiness, and central nervous system depression. Severe overdose can lead to renal failure, hepatic dysfunction, and coma. Treatment is symptomatic and supportive; gastric lavage or activated charcoal may be considered if recent ingestion.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters); Category D in the third trimester due to risk of premature closure of the ductus arteriosus. Not recommended during breastfeeding as it may pass into breast milk.
Side Effects
Contraindications
- Known hypersensitivity to Fapicitin or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Severe heart failure
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects, increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, abdominal pain, drowsiness, and central nervous system depression. Severe overdose can lead to renal failure, hepatic dysfunction, and coma. Treatment is symptomatic and supportive; gastric lavage or activated charcoal may be considered if recent ingestion.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters); Category D in the third trimester due to risk of premature closure of the ductus arteriosus. Not recommended during breastfeeding as it may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Patent pending
Clinical Trials
Phase III clinical trials demonstrated significant efficacy in reducing pain associated with osteoarthritis and post-surgical recovery, with a favorable safety profile compared to existing NSAIDs. (NCT01234567).
Lab Monitoring
- Renal function tests (creatinine, BUN)
- Liver function tests (ALT, AST)
- Complete blood count (CBC)
Doctor Notes
- Advise patients to report any signs of gastrointestinal bleeding immediately.
- Consider gastroprotective agents for high-risk patients.
- Monitor blood pressure and renal function during chronic therapy.
Patient Guidelines
- Take with food to minimize stomach upset.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Avoid alcohol while on this medication.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness. Exercise caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid prolonged exposure to sunlight if photosensitivity occurs.
- Regular exercise and a balanced diet can help manage chronic pain conditions.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.