Farin
Generic Name
Warfarin Sodium
Manufacturer
Healthcare Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| farin 5 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Farin 5 mg Tablet contains Warfarin Sodium, an anticoagulant used to prevent and treat blood clots. It works by decreasing the clotting ability of the blood.
Uses & Indications
Dosage
Adults
Initial dose typically 2-5 mg orally once daily. Dosage is highly individualized based on INR response. The target INR range is usually 2.0-3.0 for most indications, but may vary (e.g., 2.5-3.5 for mechanical heart valves). Adjust dose based on regular INR monitoring.
Elderly
Lower initial doses (e.g., 2 mg) may be required due to increased sensitivity and higher risk of bleeding. Close INR monitoring is essential.
Renal_impairment
No specific dose adjustment for mild to moderate renal impairment, but caution is advised. In severe renal impairment, close monitoring of INR and bleeding risk is necessary.
How to Take
Take Farin tablet orally once daily, preferably at the same time each day, with or without food. Do not chew or crush the tablet.
Mechanism of Action
Warfarin inhibits Vitamin K epoxide reductase, an enzyme responsible for regenerating reduced Vitamin K. This depletion of active Vitamin K leads to the inhibition of the synthesis of Vitamin K-dependent clotting factors (II, VII, IX, X) and anticoagulant proteins (C and S) in the liver, thereby preventing clot formation.
Pharmacokinetics
Onset
Initial anticoagulant effect within 24-72 hours; full therapeutic effect in 3-5 days.
Excretion
Excreted in urine and feces as inactive metabolites.
Half life
Plasma half-life varies from 20 to 60 hours, with an average of 40 hours.
Absorption
Rapid and complete absorption from the gastrointestinal tract after oral administration. Peak plasma concentrations are reached within 2-8 hours.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzymes (CYP2C9, CYP1A2, CYP3A4) into inactive hydroxylated metabolites.
Side Effects
Contraindications
- Pregnancy (causes fetal warfarin syndrome).
- Hemorrhagic tendencies or overt bleeding (e.g., gastrointestinal bleeding, cerebral hemorrhage).
- Recent or contemplated surgery of the central nervous system or eye, or traumatic surgery resulting in large open surfaces.
- Uncontrolled hypertension.
- Severe liver or kidney disease.
- History of warfarin-induced necrosis.
- Concomitant use of drugs with high bleeding risk (e.g., aspirin, NSAIDs) without careful monitoring.
Drug Interactions
Amiodarone
Significantly increases warfarin's anticoagulant effect, requiring dose reduction.
NSAIDs/Aspirin
Increased risk of bleeding due to antiplatelet effect and/or gastric irritation.
Herbal supplements (e.g., Cranberry, Ginseng, Ginkgo biloba)
May increase or decrease warfarin effect; advise caution and INR monitoring.
Antibiotics (e.g., Metronidazole, Trimethoprim/Sulfamethoxazole)
Can potentiate warfarin's effect by altering gut flora and reducing vitamin K production or inhibiting warfarin metabolism, leading to increased INR and bleeding risk.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose of Farin can lead to excessive bleeding. Treatment involves discontinuing warfarin, administering Vitamin K (oral or IV), Fresh Frozen Plasma (FFP), or Prothrombin Complex Concentrate (PCC) depending on the severity of bleeding and INR level.
Pregnancy & Lactation
Farin is contraindicated during pregnancy due to its teratogenic effects (fetal warfarin syndrome). For lactating mothers, warfarin is generally considered compatible, as only inactive metabolites are found in breast milk, but caution is advised, and consultation with a doctor is essential.
Side Effects
Contraindications
- Pregnancy (causes fetal warfarin syndrome).
- Hemorrhagic tendencies or overt bleeding (e.g., gastrointestinal bleeding, cerebral hemorrhage).
- Recent or contemplated surgery of the central nervous system or eye, or traumatic surgery resulting in large open surfaces.
- Uncontrolled hypertension.
- Severe liver or kidney disease.
- History of warfarin-induced necrosis.
- Concomitant use of drugs with high bleeding risk (e.g., aspirin, NSAIDs) without careful monitoring.
Drug Interactions
Amiodarone
Significantly increases warfarin's anticoagulant effect, requiring dose reduction.
NSAIDs/Aspirin
Increased risk of bleeding due to antiplatelet effect and/or gastric irritation.
Herbal supplements (e.g., Cranberry, Ginseng, Ginkgo biloba)
May increase or decrease warfarin effect; advise caution and INR monitoring.
Antibiotics (e.g., Metronidazole, Trimethoprim/Sulfamethoxazole)
Can potentiate warfarin's effect by altering gut flora and reducing vitamin K production or inhibiting warfarin metabolism, leading to increased INR and bleeding risk.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose of Farin can lead to excessive bleeding. Treatment involves discontinuing warfarin, administering Vitamin K (oral or IV), Fresh Frozen Plasma (FFP), or Prothrombin Complex Concentrate (PCC) depending on the severity of bleeding and INR level.
Pregnancy & Lactation
Farin is contraindicated during pregnancy due to its teratogenic effects (fetal warfarin syndrome). For lactating mothers, warfarin is generally considered compatible, as only inactive metabolites are found in breast milk, but caution is advised, and consultation with a doctor is essential.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture. Refer to the product packaging for the exact expiry date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory bodies (e.g., DGDA, FDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Warfarin has been extensively studied in numerous clinical trials to establish its efficacy and safety in various thromboembolic conditions, leading to its widespread use as a standard anticoagulant.
Lab Monitoring
- International Normalized Ratio (INR) is crucial for monitoring warfarin therapy. Initially, INR should be checked frequently (e.g., daily or every few days) until stable. Once stable, monitoring can be less frequent (e.g., weekly to monthly).
- Complete Blood Count (CBC) to monitor for anemia secondary to bleeding.
Doctor Notes
- Emphasize the critical importance of regular INR monitoring and patient education on diet and drug interactions.
- Counsel patients on identifying and reporting signs of bleeding promptly.
- Consider genetic testing (CYP2C9 and VKORC1) in selected patients to optimize initial dosing and minimize adverse events.
Patient Guidelines
- Take Farin exactly as prescribed, at the same time each day.
- Do not make any changes to your diet or medications without consulting your doctor.
- Report any signs of bleeding (e.g., unusual bruising, blood in urine/stool, prolonged nosebleeds) immediately.
- Carry an identification card stating you are taking an anticoagulant.
Missed Dose Advice
If you miss a dose, take it as soon as you remember on the same day. If it is already the next day, skip the missed dose and continue with your regular schedule. Do not double dose to make up for a missed one.
Driving Precautions
Farin generally does not impair the ability to drive or operate machinery. However, if you experience dizziness or severe fatigue due to bleeding, avoid such activities.
Lifestyle Advice
- Maintain a consistent intake of Vitamin K-rich foods rather than avoiding them entirely, as sudden changes can affect INR.
- Limit or avoid alcohol consumption as it can increase the risk of bleeding.
- Avoid activities with a high risk of injury or trauma.
- Use a soft toothbrush and electric razor to minimize bleeding risk.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Farin Brand
Other medicines available under the same brand name
