Faslodex
Generic Name
fulvestrant
Manufacturer
AstraZeneca
Country
United Kingdom/Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| faslodex 250 mg injection | ৳ 25,000.00 | N/A |
Description
Overview of the medicine
Faslodex (fulvestrant) is an estrogen receptor antagonist indicated for the treatment of hormone receptor-positive breast cancer. It acts by binding to the estrogen receptor and causing its degradation, thereby inhibiting estrogen's effects on tumor growth.
Uses & Indications
Dosage
Adults
500 mg administered intramuscularly into the buttock (two 250 mg injections, one into each buttock) on Days 1, 15, 29, and once monthly thereafter.
Elderly
No specific dose adjustment required based on age.
Renal_impairment
No dose adjustment required for mild to moderate renal impairment. Data limited for severe renal impairment; use with caution.
How to Take
For intramuscular use only. Administer as two separate 5 mL injections, one into each buttock, slowly over 1-2 minutes. Do not inject into a blood vessel or nerve.
Mechanism of Action
Fulvestrant is an estrogen receptor downregulator (ERD) that binds to the estrogen receptor with high affinity, competitively inhibiting estrogen binding. It leads to degradation of the ER protein, reducing ER levels and inhibiting estrogen-dependent tumor cell growth.
Pharmacokinetics
Onset
Sustained estrogen receptor downregulation observed within days. Clinical response varies.
Excretion
Primarily in feces (approximately 90%) via biliary excretion, with minimal renal excretion (less than 1%).
Half life
Approximately 40 days.
Absorption
Slowly absorbed after intramuscular injection, reaching peak plasma concentrations in approximately 5-7 days. Bioavailability is not well-established for IM route.
Metabolism
Primarily hepatic, via cytochrome P450 (CYP) 3A4 and other non-CYP pathways.
Side Effects
Contraindications
- Hypersensitivity to fulvestrant or any component of the formulation.
- Pregnancy and lactation.
- Severe hepatic impairment.
Drug Interactions
Anticoagulants
Caution with concomitant use due to potential for increased bleeding risk (fulvestrant is IM).
CYP3A4 Inducers
Decreased fulvestrant exposure (e.g., rifampin, phenytoin).
CYP3A4 Inhibitors
Increased fulvestrant exposure (e.g., ketoconazole, clarithromycin).
Storage
Store in a refrigerator (2°C to 8°C). Do not freeze. Protect from light.
Overdose
No specific antidote. Management involves general supportive care.
Pregnancy & Lactation
Contraindicated in pregnancy (fetal harm). Discontinue breastfeeding during treatment and for 1 year after the last dose.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Check product label, typically 2-3 years.
Availability
Hospitals, Specialized Oncology Clinics
Approval Status
FDA Approved
Patent Status
Patent expired for original formulation
Clinical Trials
Ongoing and completed trials investigating fulvestrant in various breast cancer settings, often in combination with other targeted therapies.
Lab Monitoring
- Liver function tests (ALT, AST, bilirubin) periodically.
- Regular monitoring of calcium levels, especially in patients with bone metastases.
Doctor Notes
- Emphasize proper intramuscular injection technique to avoid nerve damage or pain.
- Monitor patients for signs of venous thromboembolism.
- Consider dose adjustment in severe hepatic impairment, though not formally specified.
Patient Guidelines
- Inform healthcare provider about all medications, supplements, and herbal products.
- Report any signs of injection site reactions, swelling, or pain.
- Use effective contraception during treatment and for 1 year after the last dose.
Missed Dose Advice
If a dose is missed, administer it as soon as possible and then resume the regular schedule. Do not double the next dose.
Driving Precautions
May cause fatigue or dizziness; patients should be cautious when driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet and exercise routine.
- Avoid alcohol if it exacerbates side effects like nausea.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.