Favitab
Generic Name
Favipiravir 200 mg Tablet
Manufacturer
Beacon Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| favitab 200 mg tablet | ৳ 200.00 | ৳ 2,000.00 |
Description
Overview of the medicine
Favitab 200 mg Tablet contains Favipiravir, an antiviral medication primarily used for the treatment of certain viral infections. It works by inhibiting the viral RNA polymerase, thereby preventing viral replication. It gained prominence during the COVID-19 pandemic for its potential role in treating mild to moderate cases.
Uses & Indications
Dosage
Adults
For COVID-19 (example): Day 1: 1600 mg twice daily; Day 2-5/10: 600 mg twice daily. (Dosage varies by indication and local guidelines).
Elderly
No specific dose adjustment generally required, but caution with comorbidities.
Renal_impairment
No dose adjustment usually needed for mild to moderate impairment; caution in severe impairment.
How to Take
Oral administration. Should be taken with or without food. Complete the full course of treatment as prescribed by the doctor.
Mechanism of Action
Favipiravir is a prodrug that is metabolized intracellularly to its active form, favipiravir ribofuranosyl-5'-triphosphate (RTP). RTP is recognized as a substrate by viral RNA-dependent RNA polymerase (RdRp) and inhibits its activity, leading to termination of RNA strand synthesis and inhibition of viral replication.
Pharmacokinetics
Onset
Not typically defined for antiviral agents in terms of a single onset time, rather it's about reducing viral load over days.
Excretion
Excreted mainly by the kidneys, mostly as metabolites.
Half life
Approximately 2-5 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 2-4 hours.
Metabolism
Primarily metabolized in the liver by aldehyde oxidase and, to a lesser extent, by xanthine oxidase.
Side Effects
Contraindications
- Hypersensitivity to favipiravir or any excipients.
- Pregnancy (due to potential teratogenicity).
- Severe hepatic impairment.
- Severe renal impairment (caution).
Drug Interactions
Repaglinide
Favipiravir may increase repaglinide levels.
Pyrazinamide
May increase favipiravir plasma levels.
Theophylline
Favipiravir may increase theophylline levels.
CYP2C8 substrates
Potential for interaction.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited information on overdose. Management should be supportive and symptomatic. Hemodialysis is unlikely to be effective due to high protein binding.
Pregnancy & Lactation
Contraindicated in pregnant women due to potential teratogenicity and embryotoxicity. Effective contraception must be used by women of childbearing potential and male partners during treatment and for a specified period after. Not recommended during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved for emergency use in some countries for COVID-19 treatment, and for novel influenza in Japan.
Patent Status
Patent-expired or not under patent in many generic manufacturing countries.
Clinical Trials
Favipiravir has been evaluated in numerous clinical trials for influenza and COVID-19, demonstrating efficacy in reducing viral load and improving clinical outcomes in certain patient populations. Ongoing research continues to explore its full therapeutic potential.
Lab Monitoring
- Liver function tests (ALT, AST) periodically.
- Renal function tests if impairment is suspected or severe.
- Complete blood count (CBC) in some cases.
- Uric acid levels, especially in patients with a history of gout.
Doctor Notes
- Emphasize strict contraception during and after treatment for both male and female patients.
- Monitor liver function tests periodically, especially in patients with pre-existing hepatic conditions.
- Advise patients to report any severe side effects promptly.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop treatment early, even if you feel better.
- Use effective contraception during treatment and for a period afterwards (e.g., 7 days for women, 3 months for men).
- Report any unusual or severe side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness or lightheadedness in some individuals. Patients should be advised to assess their reaction to the drug before driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent further spread of infection.
- Stay hydrated.
- Rest adequately.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.