Feglo-FZ
Generic Name
Fexofenadine Hydrochloride + Montelukast Sodium
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| feglo fz 48 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Feglo-FZ is a combination medicine containing Fexofenadine (an antihistamine) and Montelukast (a leukotriene receptor antagonist). It is used to relieve symptoms of allergic rhinitis and chronic urticaria, and to help manage asthma in some cases.
Uses & Indications
Dosage
Adults
One tablet (Fexofenadine 48 mg + Montelukast 10 mg) once daily, preferably in the evening, with or without food.
Elderly
No specific dose adjustment is generally required, but caution is advised due to potential age-related decrease in renal or hepatic function.
Renal_impairment
Use with caution in patients with renal impairment. Lower starting dose or reduced frequency may be considered for Fexofenadine component.
How to Take
Take orally with a glass of water, with or without food. It is generally recommended to take the tablet in the evening.
Mechanism of Action
Fexofenadine selectively blocks peripheral H1-receptors, preventing histamine from causing allergy symptoms. Montelukast selectively blocks the action of leukotrienes at the CysLT1 receptor, thereby reducing inflammation, bronchoconstriction, and other allergic responses.
Pharmacokinetics
Onset
Fexofenadine: ~1 hour. Montelukast: ~24 hours for full effect in asthma.
Excretion
Fexofenadine is excreted mainly unchanged in feces (80%) and urine (11-12%). Montelukast is primarily excreted in feces via bile (approx. 86%).
Half life
Fexofenadine: 11-15 hours. Montelukast: 2.7-5.5 hours.
Absorption
Fexofenadine is rapidly absorbed, Tmax 2-3 hours. Montelukast is also rapidly absorbed, Tmax 2-4 hours.
Metabolism
Fexofenadine is minimally metabolized (approx. 5%). Montelukast is extensively metabolized by CYP3A4, 2C9, and 2C8.
Side Effects
Contraindications
- Hypersensitivity to Fexofenadine, Montelukast, or any excipients of the tablet.
Drug Interactions
Phenobarbital or Rifampin
May decrease plasma levels of Montelukast.
Erythromycin or Ketoconazole
May increase plasma levels of Fexofenadine.
Antacids (containing aluminum and magnesium)
May decrease the absorption of Fexofenadine. Separate administration by at least 2 hours.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed and the potential benefits outweigh the risks. Both Fexofenadine and Montelukast are excreted into breast milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to Fexofenadine, Montelukast, or any excipients of the tablet.
Drug Interactions
Phenobarbital or Rifampin
May decrease plasma levels of Montelukast.
Erythromycin or Ketoconazole
May increase plasma levels of Fexofenadine.
Antacids (containing aluminum and magnesium)
May decrease the absorption of Fexofenadine. Separate administration by at least 2 hours.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed and the potential benefits outweigh the risks. Both Fexofenadine and Montelukast are excreted into breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from the date of manufacture, depending on manufacturer specifications.
Availability
Available in pharmacies nationwide in Bangladesh
Approval Status
Approved by DGDA (Bangladesh) for combination products
Patent Status
Generic versions available, patent expired for active ingredients
Clinical Trials
Extensive clinical trials have established the efficacy and safety of both Fexofenadine and Montelukast individually, and in combination for the treatment of allergic rhinitis, urticaria, and asthma. Specific trials for the 48mg Fexofenadine combination might be less common.
Lab Monitoring
- No routine laboratory monitoring is typically required. Liver function tests may be considered in patients with pre-existing hepatic impairment or if Montelukast-related liver enzyme elevations are suspected.
Doctor Notes
- Ensure patient compliance, especially with evening dosing for Montelukast's optimal effect in asthma.
- Counsel patients on potential drug and food interactions, particularly with fruit juices and antacids.
- Monitor for neuropsychiatric events with Montelukast, although rare, and advise patients to report changes in mood or behavior.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor about all other medicines you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Fexofenadine is generally non-sedating, but Montelukast may cause dizziness or drowsiness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Avoid known allergens to reduce symptoms.
- Maintain good hydration by drinking plenty of fluids.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.