Feglobin
Generic Name
Ferrous Fumarate + Folic Acid + Zinc Sulfate
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| feglobin 200 mg syrup | ৳ 25.00 | N/A |
Description
Overview of the medicine
Feglobin is a comprehensive supplement containing iron, folic acid, and zinc, primarily used to treat and prevent various types of anemia, especially iron deficiency anemia, and megaloblastic anemia. It is also prescribed during pregnancy and lactation to meet increased nutritional demands.
Uses & Indications
Dosage
Adults
One capsule daily, preferably after a meal, or as directed by the physician.
Elderly
Same as adult dosage, but caution should be exercised in patients with pre-existing conditions. Consult a physician.
Renal_impairment
Use with caution and adjust dosage if necessary, under medical supervision.
How to Take
Take orally, preferably after meals to minimize gastrointestinal upset. Swallow the capsule whole with water.
Mechanism of Action
Iron is essential for hemoglobin formation and oxygen transport. Folic acid is crucial for DNA synthesis and red blood cell maturation, preventing megaloblastic anemia. Zinc plays a vital role in immune function, wound healing, and enzymatic processes.
Pharmacokinetics
Onset
Therapeutic effects are typically seen within 2-4 weeks with consistent use.
Excretion
Iron is minimally excreted; most is conserved. Folic acid is primarily excreted renally. Zinc is mainly excreted via feces, with minor renal excretion.
Half life
Iron has no true half-life; it is utilized and stored. Folic acid half-life is approximately 3-9 hours. Zinc half-life is variable depending on body stores and intake.
Absorption
Ferrous fumarate is absorbed primarily in the duodenum and upper jejunum. Folic acid is absorbed mainly in the small intestine. Zinc absorption varies but occurs primarily in the small intestine.
Metabolism
Iron is largely conserved and recycled. Folic acid is metabolized in the liver to its active forms (e.g., tetrahydrofolate). Zinc is not metabolized but integrated into various proteins and enzymes.
Side Effects
Contraindications
- Hypersensitivity to any component of the formulation.
- Patients with hemochromatosis or hemosiderosis (iron overload disorders).
- Patients receiving repeated blood transfusions.
- Non-iron deficiency anemias (e.g., aplastic anemia, hemolytic anemia) unless iron deficiency coexists.
Drug Interactions
Antacids
May reduce iron absorption. Take iron supplement at least 2 hours before or 4 hours after antacids.
Levothyroxine
Iron may reduce absorption of levothyroxine. Separate administration by at least 4 hours.
Bisphosphonates
Iron may interfere with absorption. Take iron supplement at least 30 minutes after bisphosphonates.
Tetracyclines & Quinolones
Iron can decrease the absorption of these antibiotics. Administer iron at least 2 hours apart.
Storage
Store in a cool, dry place below 30°C, away from light and moisture.
Overdose
Symptoms of overdose include severe gastrointestinal upset, abdominal pain, vomiting, diarrhea, lethargy, and potentially severe iron poisoning leading to shock, metabolic acidosis, and organ damage. Management involves gastric lavage, supportive care, and chelation therapy with deferoxamine in severe cases.
Pregnancy & Lactation
Generally considered safe and often recommended during pregnancy and lactation to meet increased iron and folic acid demands, preventing maternal and fetal deficiencies. Consult a physician before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date
Availability
Available in pharmacies and clinics
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical evidence supports the efficacy of iron, folic acid, and zinc supplementation for the treatment and prevention of respective deficiencies, particularly in at-risk populations like pregnant women.
Lab Monitoring
- Complete Blood Count (CBC) with hemoglobin and hematocrit
- Serum ferritin levels
- Red blood cell indices
- Serum folate levels
Doctor Notes
- Always confirm iron deficiency and/or folic acid deficiency through laboratory tests before initiating Feglobin therapy.
- Educate patients on potential side effects (e.g., dark stools) and dietary interactions to ensure compliance and optimal absorption.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Store the medicine in a cool, dry place, away from direct sunlight and moisture.
- Keep out of reach of children, as iron overdose can be fatal for young children.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Feglobin is not known to impair the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in iron (e.g., red meat, leafy greens) and vitamin C (e.g., citrus fruits) to enhance iron absorption.
- Avoid taking the supplement with milk, tea, or coffee, as these can hinder iron absorption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.