Femikit
Generic Name
Mifepristone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| femikit 200 mg tablet | ৳ 300.00 | N/A |
Description
Overview of the medicine
Femikit 200 mg tablet contains Mifepristone, a synthetic steroid with anti-progestational and anti-glucocorticoid activity. It is primarily used for the medical termination of early pregnancy and, at higher doses, for managing certain conditions like Cushing's syndrome.
Uses & Indications
Dosage
Adults
For medical abortion: 200 mg orally as a single dose, followed 24-48 hours later by misoprostol as directed by physician.
Elderly
No specific dose adjustment for elderly patients, but caution is advised due to potential age-related decline in organ function.
Renal_impairment
Use with caution in patients with renal impairment; no specific dose adjustments are available, but close monitoring is recommended.
How to Take
Take orally with water, usually without food. For medical abortion, strictly follow the physician's instructions regarding timing with misoprostol and subsequent follow-up.
Mechanism of Action
Mifepristone acts as a progesterone receptor antagonist, blocking the action of progesterone, which is essential for maintaining pregnancy. It also sensitizes the myometrium to prostaglandin-induced contractions, facilitating expulsion of uterine contents.
Pharmacokinetics
Onset
Effects on uterine sensitivity typically begin within 24-48 hours.
Excretion
Mainly excreted via feces (approximately 80%), with a smaller portion via urine.
Half life
Long, 18-48 hours (due to extensive enterohepatic recirculation).
Absorption
Well absorbed orally. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver, primarily via CYP3A4.
Side Effects
Contraindications
- Confirmed or suspected ectopic pregnancy
- Adrenal failure or severe asthma inadequately managed by oral corticosteroids
- Hemorrhagic disorders or concomitant anticoagulant therapy
- Known hypersensitivity to mifepristone or any component of the tablet
- Chronic adrenal insufficiency
Drug Interactions
Anticoagulants
Concomitant use with anticoagulants may increase the risk of bleeding.
CYP3A4 Inducers
CYP3A4 inducers (e.g., rifampin, phenytoin, phenobarbital, carbamazepine, St. John's wort) may decrease mifepristone plasma concentrations.
Corticosteroids
Mifepristone exhibits anti-glucocorticoid activity and may reduce the effectiveness of concomitant corticosteroid therapy.
CYP3A4 Inhibitors
Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, erythromycin, grapefruit juice) may increase mifepristone plasma concentrations.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Limited information is available regarding mifepristone overdose. In case of an overdose, symptomatic and supportive treatment should be initiated.
Pregnancy & Lactation
Mifepristone is contraindicated in pregnancy when used for its abortifacient effect. It is excreted in breast milk and is generally not recommended during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture.
Availability
Pharmacies, hospitals, clinics (often restricted access)
Approval Status
Approved (DGDA, FDA for specific indications)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of mifepristone for medical termination of early pregnancy, often in combination with misoprostol.
Lab Monitoring
- Hemoglobin levels (to monitor for excessive bleeding)
- Follow-up ultrasound or clinical examination to confirm complete abortion
Doctor Notes
- Confirm gestational age and rule out ectopic pregnancy before administration.
- Thorough patient counseling on the procedure, expected side effects, and warning signs of complications (e.g., heavy bleeding, infection).
- Emphasize the importance of the follow-up visit to confirm complete abortion and manage any complications.
Patient Guidelines
- Understand the entire procedure and potential risks before starting treatment.
- Strictly follow all instructions given by your doctor, especially regarding subsequent medication (misoprostol) and follow-up appointments.
- Seek immediate medical attention if you experience heavy bleeding, fever, severe abdominal pain, or any unusual symptoms.
Missed Dose Advice
As Femikit 200 mg is typically administered as a single dose for medical abortion, the concept of a missed dose does not generally apply. Ensure the prescribed single dose is taken as instructed.
Driving Precautions
Mifepristone may cause dizziness. Patients should be cautious when driving or operating machinery until they know how the medicine affects them.
Lifestyle Advice
- Avoid strenuous physical activity if advised by your physician.
- Manage pain with prescribed analgesics and rest as needed.
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Global Brand Names
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