Feminor
Generic Name
Norethisterone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| feminor 5 mg tablet | ৳ 6.84 | ৳ 68.40 |
Description
Overview of the medicine
Feminor 5 mg Tablet contains Norethisterone, a synthetic progestogen used to treat various menstrual disorders, endometriosis, and to postpone menstruation.
Uses & Indications
Dosage
Adults
Dosage varies by indication. For dysfunctional uterine bleeding: 5-10 mg daily for 5-10 days. For endometriosis: 5 mg daily, increasing to 10-15 mg daily if necessary, for 6-9 months. For menstrual postponement: 5 mg three times daily starting 3 days before expected period, for up to 10-14 days.
Elderly
Generally not indicated. Use with caution in specific cases.
Renal_impairment
No specific dose adjustment required, but caution is advised in severe cases.
How to Take
Take orally with water, with or without food, as directed by your doctor. It is usually taken at the same time each day.
Mechanism of Action
Norethisterone mimics the action of natural progesterone. It suppresses ovulation, alters the endometrial lining, and influences the hypothalamic-pituitary-ovarian axis to achieve its therapeutic effects.
Pharmacokinetics
Onset
Within hours for some effects, but clinical effects may take days.
Excretion
Mainly through urine (50-70%) and feces (20-40%) as metabolites.
Half life
Approximately 5 to 12 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, undergoes extensive first-pass metabolism.
Metabolism
Primarily hepatic, via reduction and hydroxylation, followed by conjugation.
Side Effects
Contraindications
- Known or suspected pregnancy
- Undiagnosed vaginal bleeding
- Severe liver disease or tumors
- Current or history of venous or arterial thromboembolic disorders (e.g., deep vein thrombosis, pulmonary embolism, stroke, myocardial infarction)
- Known or suspected hormone-dependent malignancies (e.g., breast cancer)
- Hypersensitivity to norethisterone or any component of the tablet
Drug Interactions
Insulin and oral antidiabetics
Norethisterone may alter glucose tolerance, requiring adjustment of antidiabetic medication.
Anticoagulants (e.g., warfarin)
Norethisterone may affect the action of anticoagulants; dose adjustment may be necessary.
Enzyme inhibitors (e.g., ketoconazole, ritonavir)
May increase plasma levels of norethisterone.
Enzyme inducers (e.g., rifampicin, carbamazepine, phenytoin, St. John's wort)
May reduce the efficacy of norethisterone.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, breast tenderness, dizziness, and vaginal bleeding. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Feminor is contraindicated during pregnancy. It is not recommended for use during breastfeeding as it can pass into breast milk and affect the infant.
Side Effects
Contraindications
- Known or suspected pregnancy
- Undiagnosed vaginal bleeding
- Severe liver disease or tumors
- Current or history of venous or arterial thromboembolic disorders (e.g., deep vein thrombosis, pulmonary embolism, stroke, myocardial infarction)
- Known or suspected hormone-dependent malignancies (e.g., breast cancer)
- Hypersensitivity to norethisterone or any component of the tablet
Drug Interactions
Insulin and oral antidiabetics
Norethisterone may alter glucose tolerance, requiring adjustment of antidiabetic medication.
Anticoagulants (e.g., warfarin)
Norethisterone may affect the action of anticoagulants; dose adjustment may be necessary.
Enzyme inhibitors (e.g., ketoconazole, ritonavir)
May increase plasma levels of norethisterone.
Enzyme inducers (e.g., rifampicin, carbamazepine, phenytoin, St. John's wort)
May reduce the efficacy of norethisterone.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, breast tenderness, dizziness, and vaginal bleeding. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Feminor is contraindicated during pregnancy. It is not recommended for use during breastfeeding as it can pass into breast milk and affect the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Norethisterone is a well-established drug with numerous clinical trials supporting its efficacy and safety for approved indications.
Lab Monitoring
- Liver function tests (especially with long-term use)
- Blood pressure monitoring
- Lipid profile (periodically for long-term users)
Doctor Notes
- Carefully assess patient history for contraindications, especially thromboembolic risk and hepatic dysfunction.
- Advise patients on potential for irregular bleeding, especially during initial cycles.
- Ensure patient is not pregnant before initiating treatment.
Patient Guidelines
- Take the tablet exactly as prescribed by your doctor.
- Inform your doctor about all other medications you are taking, including herbal supplements.
- Report any unusual vaginal bleeding or severe headaches immediately.
- This medicine does not protect against sexually transmitted infections.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Norethisterone may cause dizziness in some individuals. If you experience dizziness, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy lifestyle with regular exercise and a balanced diet.
- If you smoke, discuss cessation with your doctor, especially due to increased risk of thromboembolic events with hormonal therapy.
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Global Brand Names
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