Fenexi
Generic Name
Fenexifen
Manufacturer
MediCorp Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fenexi 400 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Fenexi 400 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and lower fever. It is typically prescribed for conditions like arthritis, muscle aches, dental pain, and menstrual cramps.
Uses & Indications
Dosage
Adults
400 mg orally every 6-8 hours as needed. Maximum daily dose 1200 mg.
Elderly
Lower doses may be required; caution is advised due to increased risk of side effects.
Renal_impairment
Use with caution; dose adjustment may be necessary based on creatinine clearance.
How to Take
Take Fenexi 400 mg Tablet orally, preferably with food or milk, to minimize gastrointestinal upset. Do not crush or chew the tablet; swallow it whole with a glass of water.
Mechanism of Action
Fenexifen works by inhibiting the activity of cyclooxygenase (COX) enzymes, particularly COX-1 and COX-2, which are responsible for the synthesis of prostaglandins. Prostaglandins are mediators of pain, inflammation, and fever, so by blocking their production, Fenexifen effectively reduces these symptoms.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Mainly excreted via urine, with a small portion in feces.
Half life
Approximately 2-4 hours.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzymes.
Side Effects
Contraindications
- Known hypersensitivity to Fenexifen or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
ACE Inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, lethargy, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. In severe cases, acute renal failure, coma, and convulsions may occur. Treatment is symptomatic and supportive, including gastric lavage or activated charcoal if ingested recently. Monitor vital signs and renal function.
Pregnancy & Lactation
Fenexi should be avoided during the third trimester of pregnancy due to potential risks to the fetus, including premature closure of the ductus arteriosus and impaired renal function. In the first and second trimesters, use only if clearly needed and if the potential benefit outweighs the potential risk to the fetus. Fenexifen is excreted in breast milk; therefore, use is generally not recommended during lactation. Consult a doctor.
Side Effects
Contraindications
- Known hypersensitivity to Fenexifen or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
ACE Inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, lethargy, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. In severe cases, acute renal failure, coma, and convulsions may occur. Treatment is symptomatic and supportive, including gastric lavage or activated charcoal if ingested recently. Monitor vital signs and renal function.
Pregnancy & Lactation
Fenexi should be avoided during the third trimester of pregnancy due to potential risks to the fetus, including premature closure of the ductus arteriosus and impaired renal function. In the first and second trimesters, use only if clearly needed and if the potential benefit outweighs the potential risk to the fetus. Fenexifen is excreted in breast milk; therefore, use is generally not recommended during lactation. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by local regulatory bodies
Patent Status
Off-patent
Clinical Trials
Clinical trials for Fenexifen have demonstrated its efficacy and safety in managing various pain and inflammatory conditions. Further trials are ongoing to explore its full therapeutic potential.
Lab Monitoring
- Complete Blood Count (CBC) (especially for long-term use)
- Renal function tests (Creatinine, BUN)
- Liver function tests (ALT, AST)
Doctor Notes
- Assess patient's cardiovascular and gastrointestinal risk factors before prescribing.
- Use the lowest effective dose for the shortest possible duration.
- Monitor renal function, especially in elderly patients or those with pre-existing kidney conditions.
- Advise patients on signs of serious adverse events and when to seek immediate medical attention.
Patient Guidelines
- Take with food or milk to reduce stomach upset.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Report any unusual bleeding, persistent stomach pain, or black stools immediately.
- Avoid alcohol while taking this medicine.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Fenexi may cause dizziness or drowsiness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how this medication affects them.
Lifestyle Advice
- Maintain a healthy and balanced diet.
- Limit alcohol intake.
- Stay hydrated by drinking plenty of water.
- Regular physical activity as appropriate for your condition.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.