Fenox
Generic Name
Fexofenadine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fenox 120 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Fenox 120 mg Tablet contains Fexofenadine Hydrochloride, a non-sedating antihistamine used to relieve allergy symptoms such as runny nose, sneezing, itchy or watery eyes, and itchy nose or throat. It is also used to treat chronic hives (urticaria).
Uses & Indications
Dosage
Adults
Seasonal Allergic Rhinitis: 120 mg orally once daily. Chronic Idiopathic Urticaria: 180 mg orally once daily (or 60 mg twice daily, if 180 mg is not available or suitable).
Elderly
No specific dosage adjustment is generally required.
Renal_impairment
For patients with impaired renal function, a starting dose of 60 mg once daily is recommended.
How to Take
Take Fenox 120 mg Tablet orally with water, preferably before a meal. Do not take with fruit juice (e.g., grapefruit, orange, apple juice) as it may reduce the effectiveness of the medicine.
Mechanism of Action
Fexofenadine is a selective peripheral H1-blocker. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. It does not readily cross the blood-brain barrier, resulting in less sedative effects compared to first-generation antihistamines.
Pharmacokinetics
Onset
Within 1 hour.
Excretion
Mainly excreted unchanged in feces (80%) and urine (11%).
Half life
14.4 hours.
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations reached in 2-3 hours.
Metabolism
Minimally metabolized; approximately 5% of total dose.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine or any component of the formulation.
Drug Interactions
Erythromycin and Ketoconazole
May increase plasma concentrations of fexofenadine, but this is generally not considered clinically significant.
Antacids (aluminum and magnesium hydroxide containing)
May reduce the absorption of fexofenadine. Take these antacids at least 2 hours apart from fexofenadine.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include dizziness, drowsiness, and dry mouth. Management is primarily symptomatic and supportive; there is no specific antidote. Consider gastric lavage and usual measures to remove unabsorbed drug.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Fexofenadine is excreted into breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine or any component of the formulation.
Drug Interactions
Erythromycin and Ketoconazole
May increase plasma concentrations of fexofenadine, but this is generally not considered clinically significant.
Antacids (aluminum and magnesium hydroxide containing)
May reduce the absorption of fexofenadine. Take these antacids at least 2 hours apart from fexofenadine.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include dizziness, drowsiness, and dry mouth. Management is primarily symptomatic and supportive; there is no specific antidote. Consider gastric lavage and usual measures to remove unabsorbed drug.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Fexofenadine is excreted into breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Off-patent
Clinical Trials
Extensively studied in clinical trials for seasonal allergic rhinitis and chronic idiopathic urticaria, demonstrating efficacy and safety.
Lab Monitoring
- No routine lab monitoring is generally required.
Doctor Notes
- Advise patients to avoid fruit juices. Consider renal dose adjustment. Reassure patients regarding non-sedating profile.
Patient Guidelines
- Take the tablet whole with water.
- Avoid taking with fruit juices.
- Do not exceed the recommended dose.
- Inform your doctor or pharmacist about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Fenox is generally non-sedating, but individuals react differently. If you experience drowsiness or dizziness, avoid driving or operating machinery.
Lifestyle Advice
- Avoid known allergens. Maintain good hygiene. For chronic urticaria, identify and avoid triggers.
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Global Brand Names
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