Ferintus
Generic Name
Ferric Carboxymaltose
Manufacturer
Acme Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ferintus 100 mg injection | ৳ 400.00 | N/A |
Description
Overview of the medicine
Ferintus 100 mg Injection contains Ferric Carboxymaltose, an iron carbohydrate complex used to treat iron deficiency anemia when oral iron preparations are ineffective or cannot be used.
Uses & Indications
Dosage
Adults
The cumulative dose of Ferric Carboxymaltose can be up to 1000 mg (10 vials of 100 mg) administered as a single dose or divided into multiple doses over a period, depending on iron deficiency severity. Typically, 500-1000 mg (up to 20 mg/kg body weight) per infusion.
Elderly
No specific dosage adjustment is generally needed for elderly patients, but individual assessment is recommended due to potential age-related organ function decline.
Renal_impairment
No specific dose adjustment is required in patients with renal impairment, but caution is advised, and close monitoring of iron parameters is recommended.
How to Take
Ferintus 100 mg Injection is administered intravenously by a healthcare professional, either as a slow push or an infusion diluted in normal saline.
Mechanism of Action
Ferric Carboxymaltose delivers iron directly to the reticuloendothelial system. The iron is then released slowly and incorporated into hemoglobin, myoglobin, and other iron-containing enzymes, replenishing iron stores.
Pharmacokinetics
Onset
Hemoglobin increase usually seen within 2-4 weeks after administration.
Excretion
Primarily via the reticuloendothelial system. Minimal renal excretion of intact complex.
Half life
Approximately 7-12 hours for total iron in plasma.
Absorption
Rapidly taken up by the reticuloendothelial system.
Metabolism
Iron is separated from the carbohydrate complex and incorporated into ferritin or transferrin.
Side Effects
Contraindications
- Hypersensitivity to Ferric Carboxymaltose or any excipients.
- Anemia not caused by iron deficiency (e.g., hemolytic anemia, megaloblastic anemia).
- Evidence of iron overload or disturbances in iron utilization.
- First trimester of pregnancy.
Drug Interactions
ACE Inhibitors
No specific interactions reported, but caution with concomitant medications that affect blood pressure due to potential for hypotension/hypertension with IV iron.
Oral Iron Preparations
Concomitant administration of oral iron preparations may reduce the absorption of oral iron. Oral iron therapy should be started at least 5 days after the last Ferintus injection.
Storage
Store below 30°C. Do not freeze. Keep the vial in the outer carton to protect from light. Once diluted, use immediately.
Overdose
Overdose can lead to iron overload. Symptoms include abdominal pain, nausea, vomiting, and in severe cases, shock and liver damage. Management includes symptomatic and supportive care, potentially requiring iron chelation therapy (e.g., deferoxamine).
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed after careful risk-benefit assessment by a doctor, especially avoiding the first trimester. Limited data indicate small amounts of iron are excreted in breast milk; caution is advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to Ferric Carboxymaltose or any excipients.
- Anemia not caused by iron deficiency (e.g., hemolytic anemia, megaloblastic anemia).
- Evidence of iron overload or disturbances in iron utilization.
- First trimester of pregnancy.
Drug Interactions
ACE Inhibitors
No specific interactions reported, but caution with concomitant medications that affect blood pressure due to potential for hypotension/hypertension with IV iron.
Oral Iron Preparations
Concomitant administration of oral iron preparations may reduce the absorption of oral iron. Oral iron therapy should be started at least 5 days after the last Ferintus injection.
Storage
Store below 30°C. Do not freeze. Keep the vial in the outer carton to protect from light. Once diluted, use immediately.
Overdose
Overdose can lead to iron overload. Symptoms include abdominal pain, nausea, vomiting, and in severe cases, shock and liver damage. Management includes symptomatic and supportive care, potentially requiring iron chelation therapy (e.g., deferoxamine).
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed after careful risk-benefit assessment by a doctor, especially avoiding the first trimester. Limited data indicate small amounts of iron are excreted in breast milk; caution is advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 years from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Extensive clinical trials (e.g., FERGILE, FERGICAR) have demonstrated the efficacy and safety of Ferric Carboxymaltose in various populations with iron deficiency anemia, including patients with chronic kidney disease and inflammatory bowel disease.
Lab Monitoring
- Hemoglobin (Hb)
- Serum Ferritin
- Transferrin Saturation (TSAT)
Doctor Notes
- Administer a test dose for high-risk patients or those with a history of multiple drug allergies.
- Monitor vital signs and observe the patient for signs of hypersensitivity reactions for at least 30 minutes following administration.
- Re-evaluate iron status (Hb, ferritin, TSAT) 4 weeks after the last injection to determine the need for further iron supplementation.
Patient Guidelines
- Report any immediate adverse reactions (e.g., rash, swelling, difficulty breathing) during or after the injection.
- Do not self-administer this injection; it must be given by a healthcare professional.
- Follow your doctor's instructions regarding diet and follow-up blood tests.
Missed Dose Advice
As this medicine is administered by a healthcare professional, a missed dose is unlikely. If a dose is missed, contact your doctor immediately to reschedule the administration.
Driving Precautions
Ferintus Injection may cause dizziness or lightheadedness. Patients should avoid driving or operating machinery if they experience these side effects.
Lifestyle Advice
- Maintain a balanced diet rich in iron-rich foods, but do not rely on diet alone for treating severe iron deficiency.
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