Fertil
Generic Name
Clomiphene Citrate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fertil 50 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Clomiphene citrate is a non-steroidal fertility medicine used to stimulate ovulation in women who desire pregnancy. It works by causing the pituitary gland to produce more follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which stimulate the growth and release of an egg (ovulation).
Uses & Indications
Dosage
Adults
50 mg orally once daily for 5 days, starting on day 5 of the menstrual cycle or at any time in amenorrheic patients. If ovulation does not occur, dosage may be increased to 100 mg daily for 5 days in subsequent cycles, up to a maximum of 3 cycles.
Elderly
Not typically indicated for elderly patients.
Renal_impairment
No specific dose adjustment guidelines provided, use with caution.
How to Take
Oral administration, usually starting on the 5th day of the menstrual cycle, for 5 days.
Mechanism of Action
Clomiphene is a selective estrogen receptor modulator (SERM) that binds to estrogen receptors in the hypothalamus, pituitary gland, and other estrogen-responsive tissues. By blocking these receptors, it is believed to prevent the negative feedback of estrogen, leading to an increase in GnRH, FSH, and LH secretion, which stimulates ovarian follicular growth and ovulation.
Pharmacokinetics
Onset
Ovulation typically occurs 5-10 days after the last dose of a cycle.
Excretion
Primarily excreted via feces; some via urine.
Half life
5-7 days (variable due to enterohepatic recirculation).
Absorption
Readily absorbed after oral administration.
Metabolism
Metabolized in the liver.
Side Effects
Contraindications
- •Pregnancy.
- •Undiagnosed abnormal vaginal bleeding.
- •Ovarian cysts not due to PCOS.
- •Liver disease or history of liver dysfunction.
- •Uncontrolled thyroid or adrenal dysfunction.
- •Known hypersensitivity to clomiphene citrate.
Drug Interactions
Danazol
May increase clomiphene levels.
Gonadotropins
May potentiate ovarian hyperstimulation.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms may include blurred vision, scotomata, ovarian enlargement, abdominal pain. Management is supportive, including gastric lavage if acute.
Pregnancy & Lactation
Pregnancy: Contraindicated during pregnancy (Category X). Lactation: Not recommended during lactation as it may decrease milk production.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies
Approval Status
Approved
Patent Status
Generic available
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in