Feva-Rapid (Actizorb)
Generic Name
Paracetamol (Acetaminophen)
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| feva rapid actizorb 500 mg tablet | ৳ 1.30 | ৳ 13.00 |
Description
Overview of the medicine
Feva-Rapid Actizorb 500 mg Tablet is a fast-acting formulation of paracetamol, used for the relief of mild to moderate pain and reduction of fever. The 'Actizorb' technology aims for quicker absorption and faster onset of action.
Uses & Indications
Dosage
Adults
500 mg to 1000 mg every 4-6 hours as needed. Maximum 4000 mg in 24 hours.
Elderly
Generally same as adults, but caution with hepatic or renal impairment.
Renal_impairment
Dose interval may need to be extended to 6-8 hours for severe impairment (CrCl < 10 mL/min).
How to Take
Oral administration. Tablets can be taken with or without food. For faster action, it is often recommended to take without food.
Mechanism of Action
Paracetamol works primarily by inhibiting prostaglandin synthesis in the central nervous system, which leads to its analgesic and antipyretic effects. It has weak anti-inflammatory properties.
Pharmacokinetics
Onset
Typically within 15-30 minutes due to Actizorb technology.
Excretion
Mainly excreted in urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
1-4 hours (typically 2-3 hours in adults).
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, especially with Actizorb formulation. Peak plasma concentrations are reached within 15-30 minutes.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation pathways. A small amount is metabolized by cytochrome P450 to a toxic intermediate (NAPQI), which is detoxified by glutathione.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation
- Severe hepatic impairment
Drug Interactions
Alcohol
Increased risk of liver damage with chronic alcohol consumption.
Warfarin
May increase anticoagulant effect, leading to increased bleeding risk with prolonged regular use.
Other paracetamol-containing products
Risk of overdose.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, and liver damage (which may be delayed). Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Considered safe for use during pregnancy and lactation at recommended doses. Consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation
- Severe hepatic impairment
Drug Interactions
Alcohol
Increased risk of liver damage with chronic alcohol consumption.
Warfarin
May increase anticoagulant effect, leading to increased bleeding risk with prolonged regular use.
Other paracetamol-containing products
Risk of overdose.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, and liver damage (which may be delayed). Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Considered safe for use during pregnancy and lactation at recommended doses. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from manufacturing date
Availability
Pharmacies, Drugstores, Supermarkets
Approval Status
Approved by DGDA
Patent Status
Expired (Generic available)
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of paracetamol. Specific trials for Actizorb formulations typically focus on faster onset of action and bioavailability compared to standard formulations.
Lab Monitoring
- Liver function tests (in cases of prolonged high-dose use or suspected overdose)
- Renal function tests (in patients with pre-existing renal impairment)
Doctor Notes
- Advise patients on maximum daily dose to prevent accidental overdose, especially with combination products.
- Consider liver function in patients with pre-existing hepatic disease or chronic alcohol use.
- The 'Actizorb' formulation offers a quick-acting option for rapid symptom relief.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid taking with other paracetamol-containing products.
- Consult a doctor if symptoms persist for more than 3 days (fever) or 7 days (pain).
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
Generally no effect on driving ability at recommended doses. If drowsiness or dizziness occurs (rare), avoid driving or operating machinery.
Lifestyle Advice
- Stay hydrated, especially during fever.
- Get adequate rest to support recovery.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.