Fevimol
Generic Name
Paracetamol 500 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fevimol 500 mg tablet | ৳ 0.80 | ৳ 8.00 |
Description
Overview of the medicine
Fevimol 500 mg Tablet contains Paracetamol, an analgesic and antipyretic used to relieve mild to moderate pain and reduce fever. It is widely used for headaches, muscle aches, period pain, colds, and flu symptoms.
Uses & Indications
Dosage
Adults
500 mg to 1000 mg (1-2 tablets) every 4-6 hours as needed. Maximum 4000 mg (8 tablets) in 24 hours.
Elderly
Generally same as adult dose, but caution may be advised in patients with renal or hepatic impairment.
Renal_impairment
Dose interval may need to be extended (e.g., every 6-8 hours for severe impairment). Consult a physician.
How to Take
Oral administration. Take with or without food. Do not exceed the recommended dose or duration of treatment.
Mechanism of Action
Paracetamol primarily acts by inhibiting cyclooxygenase (COX) enzymes in the central nervous system, particularly COX-2, leading to reduced prostaglandin synthesis. This inhibition results in antipyretic (fever-reducing) and analgesic (pain-relieving) effects. Unlike NSAIDs, it has minimal anti-inflammatory activity and a different mechanism regarding peripheral COX inhibition.
Pharmacokinetics
Onset
30-60 minutes for analgesia; 30 minutes for antipyresis.
Excretion
Excreted mainly in the urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
Approximately 1-4 hours, prolonged in hepatic dysfunction.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 30-60 minutes after oral administration.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation. A small portion is metabolized by cytochrome P450 to a reactive intermediate (NAPQI), which is detoxified by glutathione.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation
- Severe hepatic impairment or active liver disease
Drug Interactions
Alcohol
Increases the risk of hepatotoxicity.
Warfarin
May increase the anticoagulant effect, leading to increased bleeding risk with prolonged regular use.
Cholestyramine
Decreases absorption of paracetamol.
Other hepatotoxic drugs
Increased risk of liver damage.
Metoclopramide/Domperidone
Increases absorption rate of paracetamol.
Certain anticonvulsants (e.g., phenobarbital, phenytoin, carbamazepine)
May increase paracetamol metabolism, potentially reducing its effectiveness and increasing risk of hepatotoxicity.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, pallor, and diaphoresis, which may appear within 24 hours. Severe hepatotoxicity (liver damage) can occur, leading to liver failure and death. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote, ideally within 8-10 hours of overdose.
Pregnancy & Lactation
Considered safe for use during pregnancy and lactation when used at recommended doses for short periods. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 36 months from manufacturing date
Availability
Pharmacies, drugstores, supermarkets
Approval Status
Approved by health authorities worldwide (e.g., FDA, DGDA)
Patent Status
Generic; patent expired
WHO Essential Medicine
YesClinical Trials
Extensively studied and widely used for decades. Numerous clinical trials have confirmed its efficacy and safety for pain and fever management.
Lab Monitoring
- Liver function tests (especially in cases of suspected overdose or prolonged high-dose use)
- Renal function tests (in patients with pre-existing kidney conditions or chronic use)
Doctor Notes
- Advise patients about the maximum daily dose and the risks of overdose, especially if taking other paracetamol-containing products.
- Caution in patients with pre-existing liver disease or chronic alcohol consumption.
- N-acetylcysteine is the antidote for paracetamol overdose; administer promptly.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid taking with other paracetamol-containing products.
- Consult a doctor if pain or fever persists for more than a few days.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
Generally safe. It does not usually cause drowsiness or impair ability to drive or operate machinery. However, if any unusual side effects occur, avoid such activities.
Lifestyle Advice
- Maintain adequate hydration.
- Rest when experiencing fever or pain.
- Avoid alcohol while taking this medicine due to increased risk of liver damage.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.