Fexozen
Generic Name
Fexofenadine 120 mg tablet
Manufacturer
Drug International Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fexozen 120 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Fexozen 120 mg tablet contains Fexofenadine, a non-sedating antihistamine used to relieve allergy symptoms such as runny nose, sneezing, itchy or watery eyes, and itching of the nose or throat. It is also used to treat chronic urticaria.
Uses & Indications
Dosage
Adults
120 mg once daily or 60 mg twice daily. For chronic idiopathic urticaria, 180 mg once daily may be used.
Elderly
No specific dose adjustment is generally required, but caution is advised in elderly patients with impaired renal function.
Renal_impairment
For severe renal impairment (CrCl < 10 mL/min), initial dose of 60 mg once daily is recommended.
How to Take
Oral. Should be taken with water, preferably before a meal. Do not take with fruit juice as it may reduce absorption.
Mechanism of Action
Fexofenadine is a selective peripheral H1-receptor antagonist. It works by blocking histamine H1 receptors, thereby preventing the effects of histamine which include vasodilation, increased capillary permeability, and itching, without causing significant drowsiness.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Primarily excreted unchanged in feces (approx. 80%) and urine (approx. 11%).
Half life
14.4 hours
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached in 1-3 hours.
Metabolism
Minimally metabolized; approximately 5% of the total dose is metabolized by the liver.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine or any component of the formulation.
- Children under 6 years of age (for 120 mg tablet).
Drug Interactions
Erythromycin, Ketoconazole
May increase plasma concentrations of fexofenadine. No clinical significance generally noted, but caution advised.
Antacids containing aluminum or magnesium
May decrease absorption of fexofenadine. Take fexofenadine at least 2 hours before or after antacids.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, dizziness, and dry mouth. Treatment is supportive and symptomatic; gastric lavage or activated charcoal may be considered. Hemodialysis does not effectively remove fexofenadine.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed and the potential benefits outweigh the potential risks to the fetus. Small amounts are excreted in breast milk; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine or any component of the formulation.
- Children under 6 years of age (for 120 mg tablet).
Drug Interactions
Erythromycin, Ketoconazole
May increase plasma concentrations of fexofenadine. No clinical significance generally noted, but caution advised.
Antacids containing aluminum or magnesium
May decrease absorption of fexofenadine. Take fexofenadine at least 2 hours before or after antacids.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, dizziness, and dry mouth. Treatment is supportive and symptomatic; gastric lavage or activated charcoal may be considered. Hemodialysis does not effectively remove fexofenadine.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed and the potential benefits outweigh the potential risks to the fetus. Small amounts are excreted in breast milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated fexofenadine's efficacy and safety in treating seasonal allergic rhinitis and chronic idiopathic urticaria, showing low incidence of sedation compared to older antihistamines.
Lab Monitoring
- No specific lab monitoring is typically required for fexofenadine. Renal function may be monitored in patients with severe renal impairment.
Doctor Notes
- Advise patients about potential interaction with fruit juices.
- Counsel patients on proper administration (e.g., before meals).
- Monitor for hypersensitivity reactions.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid taking with fruit juices.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Fexofenadine is generally non-sedating, but some individuals may experience drowsiness or dizziness. Exercise caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Identify and avoid known allergens.
- Maintain good personal hygiene to reduce allergen exposure.
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Global Brand Names
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