Fix-A DS
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fix a ds 200 mg suspension | ৳ 320.00 | N/A |
Description
Overview of the medicine
Cefixime is a broad-spectrum cephalosporin antibiotic used to treat various bacterial infections, especially those of the respiratory and urinary tracts.
Uses & Indications
Dosage
Adults
Adults and children over 10 years or weighing more than 50 kg: 200-400 mg once daily or in two divided doses. For suspension, dosage is based on body weight for children.
Elderly
No specific dose adjustment is generally required unless there is severe renal impairment.
Renal_impairment
Dosage adjustment is necessary for severe renal impairment (CrCl < 20 mL/min). Usually, 25% of the standard dose.
How to Take
Administer orally with or without food. Shake the suspension well before use. Use a measuring spoon/cup provided for accurate dosing.
Mechanism of Action
Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Primarily excreted unchanged in urine and bile.
Half life
3-4 hours
Absorption
Approximately 40-50% absorbed orally. Peak plasma concentrations are reached in 2-6 hours.
Metabolism
Not significantly metabolized; small amount may be metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to cefixime or other cephalosporins
- History of anaphylactic reaction to penicillin
Drug Interactions
Probenecid
May increase cefixime plasma levels.
Carbamazepine
May increase carbamazepine levels.
Oral anticoagulants (e.g., Warfarin)
May increase prothrombin time; monitor INR.
Storage
Store dry granules below 30°C, protected from light and moisture. Keep reconstituted suspension refrigerated (2-8°C) and discard after 7-14 days.
Overdose
Symptoms may include gastrointestinal disturbances, convulsions. Treatment is symptomatic and supportive; hemodialysis or peritoneal dialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed. Excreted in low concentrations in breast milk; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to cefixime or other cephalosporins
- History of anaphylactic reaction to penicillin
Drug Interactions
Probenecid
May increase cefixime plasma levels.
Carbamazepine
May increase carbamazepine levels.
Oral anticoagulants (e.g., Warfarin)
May increase prothrombin time; monitor INR.
Storage
Store dry granules below 30°C, protected from light and moisture. Keep reconstituted suspension refrigerated (2-8°C) and discard after 7-14 days.
Overdose
Symptoms may include gastrointestinal disturbances, convulsions. Treatment is symptomatic and supportive; hemodialysis or peritoneal dialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed. Excreted in low concentrations in breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months for dry powder (unreconstituted). Reconstituted suspension is stable for 7-14 days at refrigerated temperatures.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established cefixime's efficacy and safety in various bacterial infections, particularly in pediatric and adult populations.
Lab Monitoring
- Renal function tests (for prolonged therapy or renal impairment)
- INR monitoring (if co-administered with anticoagulants)
Doctor Notes
- Advise patients to complete the full course of treatment.
- Counsel on proper reconstitution and administration of suspension, especially for pediatric patients.
- Monitor for signs of allergic reactions, particularly in patients with a history of penicillin allergy.
Patient Guidelines
- Complete the full course of treatment even if you feel better.
- Do not share this medicine with others.
- Shake well before each use.
- Take with or without food.
Missed Dose Advice
Take the missed dose as soon as you remember. If it's almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness in some individuals, caution is advised when driving or operating machinery.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol during treatment as it may exacerbate side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.