Fixal
Generic Name
Fexofenadine Hydrochloride
Manufacturer
ACME Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fixal 30 mg tablet | ৳ 3.51 | ৳ 35.10 |
| fixal 60 mg tablet | ৳ 5.02 | ৳ 50.20 |
| fixal 120 mg tablet | ৳ 9.00 | ৳ 90.00 |
| fixal 180 mg tablet | ৳ 10.00 | ৳ 100.00 |
| fixal 30 mg suspension | ৳ 55.00 | N/A |
Description
Overview of the medicine
Fixal contains Fexofenadine Hydrochloride, a non-sedating antihistamine used to relieve symptoms of seasonal allergic rhinitis (hay fever) and chronic idiopathic urticaria (hives). It helps alleviate sneezing, runny nose, itchy nose/palate/throat, itchy/watery/red eyes, and skin itching and rash.
Uses & Indications
Dosage
Adults
For seasonal allergic rhinitis: 60 mg twice daily or 120 mg once daily or 180 mg once daily. For chronic idiopathic urticaria: 60 mg twice daily or 180 mg once daily.
Elderly
No dosage adjustment is generally needed based on age alone, but renal function should be considered.
Renal_impairment
For patients with impaired renal function (creatinine clearance less than 80 mL/min): Start with 60 mg once daily for both indications.
How to Take
Take the tablet orally with water. It is recommended to take it before a meal, as absorption may be reduced by high-fat meals and fruit juices. Do not take with fruit juices like grapefruit, orange, or apple juice.
Mechanism of Action
Fexofenadine is a selective peripheral H1-blocker. It binds to histamine H1 receptors, preventing histamine from exerting its effects, thereby reducing allergic symptoms without causing significant central nervous system depression.
Pharmacokinetics
Onset
Onset of action is usually within 1 hour.
Excretion
Primarily excreted unchanged in feces (about 80%) and urine (about 11%).
Half life
The elimination half-life is approximately 14.4 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations reached in 1-3 hours.
Metabolism
Minimally metabolized; approximately 5% undergoes hepatic metabolism.
Side Effects
Contraindications
- Known hypersensitivity to Fexofenadine Hydrochloride or any of the excipients.
Drug Interactions
Erythromycin or Ketoconazole
Can increase Fexofenadine plasma concentrations (though clinical significance is minimal).
Antacids (aluminum and magnesium hydroxide containing)
Can decrease absorption of Fexofenadine. Separate administration by at least 2 hours.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In cases of overdose, patients have reported dizziness, drowsiness, and dry mouth. Management should be symptomatic and supportive, including gastric lavage and observation.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether Fexofenadine is excreted in human milk; however, other antihistamines are. Use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
Clinical Trials
Fexofenadine has undergone extensive clinical trials demonstrating its efficacy and safety for seasonal allergic rhinitis and chronic idiopathic urticaria.
Lab Monitoring
- No specific laboratory monitoring is generally required for Fexofenadine. Renal function may be monitored in patients with pre-existing renal impairment.
Doctor Notes
- Advise patients to avoid fruit juices due to potential interaction.
- Consider dosage adjustment for patients with renal impairment.
Patient Guidelines
- Take Fixal as prescribed by your doctor and do not exceed the recommended dose.
- Avoid taking Fixal with fruit juices, as this can reduce its effectiveness.
- If you experience any unusual or severe side effects, consult your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Fexofenadine is generally non-sedating, but individual responses can vary. Patients should assess their response before driving or operating machinery.
Lifestyle Advice
- Identify and avoid known allergens that trigger your symptoms.
- Maintain a clean indoor environment to reduce exposure to dust mites and pet dander.
- Stay hydrated.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.