Flacort
Generic Name
Deflazacort
Manufacturer
Healthcare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| flacort 6 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Flacort 6 mg Tablet contains Deflazacort, a corticosteroid used to treat various inflammatory and autoimmune conditions. It helps to reduce inflammation and suppress the immune system.
Uses & Indications
Dosage
Adults
Initial dose of 6-90 mg daily, adjusted according to patient response and condition. Often 6-18 mg daily for maintenance.
Elderly
No specific dose adjustment required, but use with caution due to potential for increased side effects.
Renal_impairment
No specific dose adjustment for mild to moderate renal impairment. Use with caution in severe renal impairment.
How to Take
Orally, usually once daily, preferably in the morning with food to reduce gastric irritation.
Mechanism of Action
Deflazacort is a glucocorticoid that binds to glucocorticoid receptors in the cytoplasm, forming a complex that translocates to the nucleus. This complex modulates gene expression, leading to anti-inflammatory and immunosuppressive effects by decreasing the production of inflammatory mediators and suppressing immune cell activity.
Pharmacokinetics
Onset
Anti-inflammatory effects typically seen within hours.
Excretion
Mainly excreted via the kidneys (approximately 70% in urine) and some in feces.
Half life
Plasma half-life of active metabolite (21-desacetyl deflazacort) is 1.1-1.9 hours. Biological half-life is longer.
Absorption
Well absorbed from the gastrointestinal tract. Bioavailability is about 70%.
Metabolism
Rapidly metabolized in the liver to its active metabolite, 21-desacetyl deflazacort.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to deflazacort or any component of the formulation
- Administration of live or live-attenuated vaccines during treatment (in high doses)
Drug Interactions
NSAIDs
Increased risk of gastrointestinal ulceration.
Oral anticoagulants
Effects may be altered.
Diuretics (Thiazide and loop)
Increased potassium loss.
Insulin, Oral hypoglycemic agents
May reduce their hypoglycemic effect.
Rifampicin, Phenytoin, Barbiturates
May reduce the effect of deflazacort.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include exacerbation of common side effects. Management is symptomatic and supportive. Electrolyte balance should be monitored.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Small amounts are excreted in breast milk; caution should be exercised. Consult a doctor.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to deflazacort or any component of the formulation
- Administration of live or live-attenuated vaccines during treatment (in high doses)
Drug Interactions
NSAIDs
Increased risk of gastrointestinal ulceration.
Oral anticoagulants
Effects may be altered.
Diuretics (Thiazide and loop)
Increased potassium loss.
Insulin, Oral hypoglycemic agents
May reduce their hypoglycemic effect.
Rifampicin, Phenytoin, Barbiturates
May reduce the effect of deflazacort.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include exacerbation of common side effects. Management is symptomatic and supportive. Electrolyte balance should be monitored.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Small amounts are excreted in breast milk; caution should be exercised. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved by drug regulatory authorities (e.g., DGDA)
Patent Status
Generic available (likely off-patent)
Clinical Trials
Deflazacort has been studied in numerous clinical trials for its efficacy in Duchenne muscular dystrophy, rheumatoid arthritis, and other inflammatory conditions. Recent trials focus on long-term safety and comparative efficacy.
Lab Monitoring
- Blood glucose levels
- Blood pressure
- Electrolyte levels (especially potassium)
- Bone mineral density (for long-term use)
Doctor Notes
- Counsel patients on the importance of not abruptly discontinuing the medication.
- Monitor for signs of infection, glycemic control, blood pressure, and bone density.
- Consider prophylactic measures for osteoporosis in long-term therapy.
Patient Guidelines
- Do not stop taking Flacort abruptly, as it can cause withdrawal symptoms. Always follow your doctor's instructions.
- Report any signs of infection immediately.
- Avoid contact with people who have infections like chickenpox or measles.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Flacort generally does not impair driving ability. However, if you experience dizziness or visual disturbances, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D.
- Engage in regular, moderate exercise to maintain bone and muscle health.
- Avoid excessive alcohol consumption and smoking.
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