Medicine Information

Flexi

Name: Flexi
Brand: Flexi
Rating: 4.5 (117 reviews)

Tablet100 mgNon-steroidal Anti-inflammatory Drug (NSAID)ATC: M01AB16

Generic Name

flexi-100-mg-tablet

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
flexi 100 mg tablet	৳ 7.00	৳ 70.00

Description

Overview of the medicine

Flexi 100 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation associated with various musculoskeletal conditions, such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It works by reducing the production of certain natural substances in the body that cause inflammation.

Uses & Indications

Osteoarthritis

Rheumatoid Arthritis

Ankylosing Spondylitis

Other painful musculoskeletal conditions (e.g., sprains, strains, low back pain)

Dental pain

Post-operative pain

Dosage

Adults

The recommended dose is 100 mg twice daily, one tablet in the morning and one in the evening. It should be taken with or after food.

Elderly

No specific dose adjustment is usually required, but caution should be exercised. The lowest effective dose should be used for the shortest possible duration.

Renal_impairment

In mild to moderate renal impairment, no dose adjustment is usually necessary. However, caution is advised, and regular monitoring of renal function is recommended. Contraindicated in severe renal impairment.

How to Take

Take the tablet whole with a glass of water, with or immediately after food. Do not chew or crush the tablet.

Mechanism of Action

Flexi (Aceclofenac) primarily acts by inhibiting cyclooxygenase (COX) enzymes, particularly COX-2, which are responsible for the synthesis of prostaglandins. Prostaglandins are inflammatory mediators that cause pain, swelling, and fever. By reducing prostaglandin production, Aceclofenac exerts its anti-inflammatory, analgesic, and antipyretic effects.

Pharmacokinetics

Onset

Within 30-60 minutes for analgesic effect.

Excretion

Excreted mainly via urine (approximately two-thirds) and faeces (approximately one-third) as metabolites. Only a small fraction is excreted as unchanged drug.

Half life

Approximately 4-4.3 hours.

Absorption

Rapidly and completely absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are reached approximately 1.25 to 3 hours after administration.

Metabolism

Extensively metabolized in the liver, primarily via cytochrome P450 (CYP2C9) to 4'-hydroxyaceclofenac, its main metabolite.

Side Effects

Contraindications

Hypersensitivity to Aceclofenac or any other NSAID (e.g., aspirin, ibuprofen)
History of gastrointestinal bleeding or perforation related to previous NSAID therapy
Active or recurrent peptic ulcer/haemorrhage
Severe heart failure, hepatic failure, or renal failure
Last trimester of pregnancy

Drug Interactions

Lithium

Increased plasma lithium levels.

Methotrexate

Increased plasma levels of methotrexate, potentially leading to toxicity.

Other NSAIDs

Increased risk of adverse effects, concurrent use not recommended.

Corticosteroids

Increased risk of gastrointestinal ulceration or bleeding.

Diuretics and ACE inhibitors

Reduced efficacy of these drugs and increased risk of renal impairment.

Warfarin and other anticoagulants

Increased risk of bleeding.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding, rarely diarrhoea, disorientation, excitation, coma, drowsiness, dizziness, tinnitus, fainting and convulsions. Management typically involves symptomatic and supportive treatment. Gastric lavage and activated charcoal may be considered if ingestion was recent. Monitor renal function and blood pressure.

Pregnancy & Lactation

Flexi 100 mg Tablet should be avoided during the third trimester of pregnancy due to potential risks to the fetus and complications during delivery. During the first two trimesters, it should only be used if the potential benefit outweighs the risk and under strict medical supervision. It is not recommended during breastfeeding as Aceclofenac may pass into breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per blister strip30 tablets per box

Shelf Life

36 months from manufacturing date.

Availability

Available in pharmacies and hospitals nationwide

Approval Status

Approved by DGDA

Patent Status

Generic available

Clinical Trials

Aceclofenac has undergone numerous clinical trials demonstrating its efficacy and safety in various pain and inflammatory conditions, leading to its widespread approval and use globally.

Lab Monitoring

Liver function tests (ALT, AST, ALP) periodically, especially in long-term treatment.
Renal function tests (Creatinine, BUN) periodically, especially in elderly or patients with pre-existing renal impairment.
Complete blood count (CBC) to monitor for anemia, particularly with prolonged use.

Doctor Notes

Assess cardiovascular and gastrointestinal risk factors before prescribing NSAIDs.
Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
Monitor renal function, liver function, and blood pressure periodically in patients on long-term therapy.
Advise patients on signs and symptoms of GI bleeding and serious cardiovascular events.

Patient Guidelines

Take this medicine exactly as prescribed by your doctor.
Always take with food or immediately after to minimize stomach upset.
Do not exceed the recommended dose.
Report any unusual symptoms, especially gastrointestinal bleeding (black, tarry stools; vomiting blood) or severe skin reactions, to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Flexi 100 mg Tablet may cause dizziness, vertigo, or visual disturbances in some individuals. If you experience these effects, avoid driving or operating machinery until you know how the medicine affects you.

Lifestyle Advice

Avoid smoking and excessive alcohol consumption, as these can increase the risk of stomach ulcers and bleeding.
Maintain a healthy diet and stay hydrated.
Engage in regular, moderate exercise if appropriate for your condition.

Alternative Medicines in Bangladesh

Similar medicines available in the market

Aceclofenac 100mg Tablet (Square Pharmaceuticals Ltd.)Acelo 100mg Tablet (Incepta Pharmaceuticals Ltd.)Acenac 100mg Tablet (Beximco Pharmaceuticals Ltd.)