Medicine Information

Fliban

Name: Fliban
Brand: Fliban
Rating: 4.5 (117 reviews)

Tablet100 mgTreatment for Hypoactive Sexual Desire Disorder (HSDD) in premenopausal womenATC: N/A (Not specifically classified under standard ATC system for HSDD)

Generic Name

Flibanserin

Manufacturer

Generic Pharmaceutical Company

Country

Bangladesh (or other manufacturing country)

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
fliban 100 mg tablet	৳ 50.00	৳ 500.00

Description

Overview of the medicine

Flibanserin 100 mg Tablet is a non-hormonal medication used to treat acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women. It helps to restore sexual desire by affecting neurotransmitters in the brain.

Uses & Indications

Treatment of acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women.

To increase the number of satisfying sexual events.

To reduce distress from low sexual desire.

Dosage

Adults

100 mg orally once daily at bedtime.

Elderly

Not recommended; safety and efficacy not established in postmenopausal or elderly women.

Renal_impairment

No dose adjustment needed for mild to moderate renal impairment. Not studied in severe renal impairment.

How to Take

Take orally once daily at bedtime. Do not take with alcohol. Swallow the tablet whole with water.

Mechanism of Action

Flibanserin acts as a postsynaptic 5-HT1A receptor agonist and a 5-HT2A receptor antagonist, as well as a D4 receptor antagonist. It helps to modulate neurotransmitter activity in the brain, rebalancing the inhibitory and excitatory systems to improve sexual desire.

Pharmacokinetics

Onset

Gradual; clinical effect may take 4-8 weeks.

Excretion

Excreted primarily in feces (51%) and urine (44%) as metabolites.

Half life

Approximately 11 hours (terminal half-life).

Absorption

Rapidly absorbed; peak plasma concentrations reached within 0.5-3 hours.

Metabolism

Extensively metabolized primarily by CYP3A4 and to a lesser extent by CYP2C19.

Side Effects

Contraindications

Concomitant use with alcohol (risk of severe hypotension and syncope).
Concomitant use with moderate or strong CYP3A4 inhibitors.
Hepatic impairment (liver problems).
Known hypersensitivity to flibanserin.

Drug Interactions

Alcohol

Increases risk of severe hypotension and syncope.

Oral Contraceptives

May increase flibanserin exposure, requiring caution.

Central Nervous System (CNS) Depressants

Increased risk of sedation and dizziness.

CYP3A4 Inducers (e.g., rifampin, St. John's Wort)

Decreases flibanserin concentrations, potentially reducing efficacy.

CYP3A4 Inhibitors (e.g., ketoconazole, fluconazole, grapefruit juice)

Significantly increases flibanserin concentrations, leading to hypotension and syncope.

Storage

Store at room temperature (20°C to 25°C), away from moisture and light. Keep out of reach of children.

Overdose

Symptoms of overdose include somnolence, sedation, nausea, dizziness. Management is symptomatic and supportive, including maintaining an open airway, monitoring vital signs, and gastric decontamination if appropriate.

Pregnancy & Lactation

Not recommended during pregnancy due to potential for fetal harm (animal studies showed adverse effects). Avoid during lactation; it is unknown if flibanserin is excreted in human milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets30 tablets

Shelf Life

Typically 24-36 months from manufacturing date.

Availability

Pharmacies

Approval Status

FDA Approved (2015)

Patent Status

Generic available

Clinical Trials

Flibanserin's efficacy and safety were established through several placebo-controlled clinical trials in premenopausal women with HSDD.

Lab Monitoring

No routine lab monitoring is required. However, assess for hepatic impairment before initiation and periodically in patients with risk factors.

Doctor Notes

Counsel patients carefully on the absolute contraindication of alcohol consumption and the risk of severe hypotension and syncope.
Emphasize that flibanserin is for acquired, generalized HSDD in premenopausal women only.
Assess for hepatic impairment prior to initiation.
Discontinue if no improvement is seen after 8 weeks.

Patient Guidelines

Take the tablet at bedtime.
Do not consume alcohol while taking this medicine.
Be aware of the risk of dizziness, somnolence, and fainting.
Inform your doctor about all other medications you are taking.

Missed Dose Advice

If a dose is missed, do not take the missed dose the next morning. Take the next dose at bedtime the following day. Do not double the dose to make up for a missed one.