Flucid
Generic Name
Fluconazole
Manufacturer
MediPharma Bangladesh
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| flucid 50 mg capsule | ৳ 8.00 | N/A |
Description
Overview of the medicine
Flucid (Fluconazole) is an antifungal medication used to treat a variety of fungal and yeast infections. It belongs to the triazole class of antifungal agents.
Uses & Indications
Dosage
Adults
For vaginal candidiasis: A single 150 mg oral dose. For oropharyngeal candidiasis: 50-100 mg once daily for 7-14 days. For systemic candidiasis: 400 mg on day 1, then 200-400 mg once daily. Dosage varies significantly by indication; consult a physician.
Elderly
No dose adjustment is typically needed unless there is evidence of renal impairment. Monitor renal function.
Renal_impairment
For patients with creatinine clearance less than 50 mL/min, the dose should be reduced by 50% after a normal initial loading dose. For hemodialysis patients, a single dose should be given after each dialysis session.
How to Take
Flucid capsules can be taken orally, with or without food. Swallow the capsule whole with a glass of water. Do not chew or crush.
Mechanism of Action
Fluconazole inhibits fungal cytochrome P450-dependent 14α-demethylation of lanosterol, which is an essential step in fungal ergosterol biosynthesis. This inhibition leads to the accumulation of 14α-methyl sterols and a decrease in ergosterol, thereby impairing fungal cell membrane function.
Pharmacokinetics
Onset
Clinical improvement typically seen within a few days, depending on the type and severity of infection.
Excretion
Primarily renal; approximately 80% of the dose is excreted unchanged in the urine. Renal clearance is proportional to creatinine clearance.
Half life
Approximately 30 hours, allowing for once-daily dosing for many indications.
Absorption
Well absorbed orally, with bioavailability greater than 90%. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Minimally metabolized; approximately 11% of the dose is metabolized to less active metabolites. It is a potent inhibitor of CYP2C9 and a moderate inhibitor of CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to fluconazole or any of its excipients.
- Co-administration with drugs known to prolong the QT interval and which are metabolized by the cytochrome P450 (CYP) 3A4 enzyme, such as terfenadine and cisapride.
Drug Interactions
Warfarin
Increased prothrombin time; monitor INR closely.
Phenytoin
Increased phenytoin levels; monitor phenytoin concentrations.
Rifampicin
Decreased fluconazole levels; consider increasing fluconazole dose.
Cyclosporine
Increased cyclosporine levels; monitor cyclosporine concentrations.
Hydrochlorothiazide
Increased plasma concentrations of fluconazole.
Statins (e.g., atorvastatin)
Increased statin levels, leading to increased risk of myopathy/rhabdomyolysis.
Benzodiazepines (e.g., midazolam)
Increased benzodiazepine levels; monitor for sedation.
Oral hypoglycemics (e.g., sulfonylureas)
Increased plasma concentration of sulfonylureas; monitor blood glucose.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include hallucinations and paranoid behavior. Treatment should be symptomatic and supportive. Gastric lavage may be considered. Hemodialysis significantly reduces plasma levels of fluconazole.
Pregnancy & Lactation
Pregnancy: Category D for prolonged or high-dose use; Category C for single-dose use in vaginal candidiasis. Should only be used if the potential benefit justifies the potential risk to the fetus. Lactation: Fluconazole is excreted in breast milk. Caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Fluconazole has undergone extensive clinical trials demonstrating its efficacy and safety for various fungal infections across different patient populations.
Lab Monitoring
- Liver function tests (LFTs) should be monitored, especially in patients with pre-existing liver conditions or during prolonged therapy.
- Renal function should be monitored in elderly patients and those with renal impairment.
Doctor Notes
- Emphasize adherence to the full treatment course to prevent resistance and recurrence.
- Caution in patients with pre-existing liver disease; monitor LFTs closely.
- Awareness of significant drug interactions, especially with warfarin, oral hypoglycemics, and drugs affecting QT interval.
Patient Guidelines
- Take the medication exactly as prescribed by your doctor and complete the full course of treatment, even if symptoms improve.
- Do not stop taking Flucid without consulting your doctor.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Flucid may cause dizziness or seizures in some individuals. If you experience these side effects, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain good personal hygiene to prevent recurrence of fungal infections.
- Avoid sharing personal items like towels or clothing.
- If you have vaginal candidiasis, avoid tight-fitting clothing and opt for cotton underwear.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.