Fludax
Generic Name
Fluda
Manufacturer
PharmaGen Corp.
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fluda 50 mg capsule | ৳ 8.02 | N/A |
Description
Overview of the medicine
Fluda 50 mg Capsule is an antidepressant medication primarily used for the treatment of major depressive disorder, generalized anxiety disorder, and panic disorder. It helps restore the balance of a certain natural substance (serotonin) in the brain, thereby improving mood and reducing anxiety.
Uses & Indications
Dosage
Adults
Initial dose 25 mg once daily, may be increased to 50 mg after one week. Max dose 100 mg daily.
Elderly
Initial dose 25 mg once daily, cautious titration due to potential increased sensitivity.
Renal_impairment
No dosage adjustment needed for mild to moderate impairment; use with caution in severe impairment.
How to Take
Take orally once daily, with or without food. Swallow the capsule whole; do not chew, crush, or open.
Mechanism of Action
Fluda selectively inhibits the reuptake of serotonin (5-HT) by the presynaptic neuron, thereby increasing the concentration of serotonin in the synaptic cleft. This increased availability of serotonin is thought to contribute to its antidepressant and anxiolytic effects.
Pharmacokinetics
Onset
Antidepressant effects may take 2-4 weeks to become noticeable.
Excretion
Excreted primarily in the urine (approximately 60%) and feces (approximately 35%) as metabolites.
Half life
Approximately 20-24 hours.
Absorption
Well absorbed orally, peak plasma concentrations reached within 4-8 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP2D6 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Fluda or any component of the formulation
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOIs
- Concomitant use with thioridazine or pimozide
Drug Interactions
MAOIs
Risk of serotonin syndrome. Concomitant use is contraindicated.
Warfarin
May increase anticoagulant effect, requiring dose adjustment of warfarin.
NSAIDs/Aspirin
Increased risk of bleeding.
SSRIs/SNRIs/Tricyclic Antidepressants
Increased risk of serotonin syndrome.
Storage
Store at room temperature (below 30°C). Protect from moisture and light. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, nausea, vomiting, tachycardia, tremor, and seizures. Treatment is symptomatic and supportive, including maintaining an open airway, cardiac monitoring, and administration of activated charcoal. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk; a decision should be made whether to discontinue nursing or the drug, considering the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to Fluda or any component of the formulation
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOIs
- Concomitant use with thioridazine or pimozide
Drug Interactions
MAOIs
Risk of serotonin syndrome. Concomitant use is contraindicated.
Warfarin
May increase anticoagulant effect, requiring dose adjustment of warfarin.
NSAIDs/Aspirin
Increased risk of bleeding.
SSRIs/SNRIs/Tricyclic Antidepressants
Increased risk of serotonin syndrome.
Storage
Store at room temperature (below 30°C). Protect from moisture and light. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, nausea, vomiting, tachycardia, tremor, and seizures. Treatment is symptomatic and supportive, including maintaining an open airway, cardiac monitoring, and administration of activated charcoal. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk; a decision should be made whether to discontinue nursing or the drug, considering the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Patent expired, generic available
Clinical Trials
Fluda has undergone multiple placebo-controlled and active-controlled clinical trials demonstrating its efficacy and safety in the approved indications. Long-term studies are ongoing to evaluate its extended use.
Lab Monitoring
- Monitor serum sodium levels periodically, especially in elderly patients or those on diuretics, due to risk of hyponatremia.
Doctor Notes
- Counsel patients on delayed onset of action and importance of adherence.
- Monitor for suicidal ideation, especially in initial treatment phase and during dose adjustments.
- Gradual tapering is crucial to avoid discontinuation syndrome.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking Fluda suddenly, as it may lead to withdrawal symptoms. Your doctor will gradually reduce your dose.
- It may take several weeks for the full antidepressant effect to be felt.
- Report any worsening of depression or suicidal thoughts to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Fluda may cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Avoid alcohol and illicit drugs.
- Engage in stress-reducing activities such as yoga or meditation.
- Ensure adequate sleep.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.