Flumark
Generic Name
Flucloxacillin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| flumark 500 mg capsule | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Flucloxacillin is an antibiotic used to treat a wide range of bacterial infections, particularly those caused by penicillinase-producing Staphylococci and Streptococci. It is effective against skin and soft tissue infections, bone and joint infections, respiratory tract infections, and other systemic infections.
Uses & Indications
Dosage
Adults
Oral: 250-500 mg every 6 hours, usually 30-60 minutes before meals. For severe infections, up to 1 g every 6 hours.
Elderly
Similar to adult dosage, but dose adjustment may be necessary in patients with significant renal impairment.
Renal_impairment
For creatinine clearance <10 mL/min, the dose should be reduced or the dosage interval extended (e.g., 250 mg every 8-12 hours).
How to Take
Take orally, preferably 30-60 minutes before meals, with a glass of water. Do not chew or crush the capsule.
Mechanism of Action
Flucloxacillin is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). Its beta-lactam structure is protected against hydrolysis by beta-lactamase enzymes, making it effective against beta-lactamase producing bacteria.
Pharmacokinetics
Onset
Rapid, with therapeutic concentrations achieved soon after administration.
Excretion
Primarily excreted by the kidneys, with 60-70% of the dose eliminated unchanged in the urine within 6 hours. Also undergoes biliary excretion.
Half life
Approximately 0.5 to 1.5 hours in adults with normal renal function.
Absorption
Well absorbed orally, especially when taken on an empty stomach. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Partially metabolized in the liver to inactive metabolites. About 10-20% of the drug is metabolized.
Side Effects
Contraindications
- Known hypersensitivity to penicillin or other beta-lactam antibiotics
- History of flucloxacillin-associated jaundice or hepatic dysfunction
Drug Interactions
Warfarin
Flucloxacillin may increase the anticoagulant effect of warfarin. Close monitoring of INR is required.
Methotrexate
Flucloxacillin may decrease the renal excretion of methotrexate, increasing its toxicity.
Oral Contraceptives
May reduce the efficacy of oral contraceptives; advise additional contraceptive methods.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include gastrointestinal disturbances like nausea, vomiting, and diarrhea, as well as electrolyte imbalance. Treatment is symptomatic and supportive. Discontinue the drug.
Pregnancy & Lactation
Pregnancy Category B. Flucloxacillin crosses the placenta but is not associated with an increased risk of malformations. Use with caution. Generally considered safe during lactation, but small amounts are excreted in breast milk; monitor infants for gastrointestinal disturbances or candidiasis.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved (e.g., DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Flucloxacillin is a well-established antibiotic. Clinical trials generally focus on specific indications, comparisons with newer antibiotics, or resistance patterns rather than initial efficacy.
Lab Monitoring
- Liver function tests (LFTs) if treatment exceeds 14 days or in patients with pre-existing hepatic impairment
- Renal function monitoring in patients with renal impairment
- Complete Blood Count (CBC) in rare cases of suspected hematological reactions
Doctor Notes
- Emphasize the importance of completing the full course to prevent resistance.
- Advise patients to take on an empty stomach for optimal absorption.
- Monitor liver function tests if treatment extends beyond 14 days or in patients with hepatic impairment.
- Educate on potential signs of cholestatic jaundice (e.g., persistent nausea, jaundice, dark urine, pale stools) and advise immediate medical attention if these occur.
Patient Guidelines
- Complete the full course of antibiotics as prescribed, even if you feel better, to prevent recurrence and resistance.
- Do not share this medicine with others.
- Report any signs of allergic reactions (e.g., severe rash, swelling, difficulty breathing) immediately.
- Take on an empty stomach for better absorption.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
Generally, flucloxacillin does not affect the ability to drive or operate machinery. However, if you experience dizziness or other side effects that may impair concentration, avoid these activities.
Lifestyle Advice
- Maintain good personal hygiene, especially for skin infections.
- Stay hydrated by drinking plenty of fluids.
- Avoid alcohol consumption during treatment if experiencing gastrointestinal side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.