Flutec-DS
Generic Name
Fluconazole
Manufacturer
Healthcare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| flutec ds 500 mg capsule | ৳ 10.00 | N/A |
Description
Overview of the medicine
Fluconazole is an antifungal medication belonging to the azole class. It works by inhibiting the growth of fungi. Flutec-DS 500 mg Capsule is primarily used to treat various fungal infections, including vaginal candidiasis, oral thrush, esophageal candidiasis, and systemic fungal infections. The 500 mg strength is typically used for severe or specific types of infections requiring higher doses or for pulse dosing regimens.
Uses & Indications
Dosage
Adults
Dosage varies based on the type and severity of the fungal infection. For severe or refractory vaginal candidiasis, a single oral dose of 500 mg may be administered. For other systemic infections, it may be used as a loading dose (e.g., 500 mg on day 1) or as part of a pulse dosing regimen, as directed by a physician. Refer to specific guidelines for complex infections.
Elderly
No dosage adjustment is usually required in elderly patients with normal renal function. For elderly patients with renal impairment, dosage adjustment is necessary based on creatinine clearance.
Renal_impairment
For patients with creatinine clearance less than 50 mL/min, the dose should be reduced by 50% after an initial normal loading dose. For patients on regular dialysis, a single dose should be given after each dialysis session.
How to Take
Flutec-DS 500 mg Capsule should be taken orally, with or without food, as directed by a healthcare professional. Swallow the capsule whole with a glass of water.
Mechanism of Action
Fluconazole inhibits fungal cytochrome P450-dependent 14-alpha-demethylase, an enzyme crucial for the biosynthesis of ergosterol in the fungal cell membrane. This inhibition leads to the accumulation of 14-alpha-methyl sterols and a corresponding decrease in ergosterol, causing increased permeability and leakage of essential intracellular components, ultimately leading to fungal cell death.
Pharmacokinetics
Onset
Clinical improvement typically seen within a few days, depending on the type and severity of infection.
Excretion
Primarily excreted unchanged by the kidneys; approximately 80% of the administered dose appears in the urine as unchanged drug.
Half life
Approximately 30 hours (range 20-50 hours), which allows for once-daily dosing.
Absorption
Well absorbed orally; bioavailability is approximately 90% and is not affected by food. Peak plasma concentrations are achieved within 0.5 to 1.5 hours after oral administration.
Metabolism
Minimally metabolized; approximately 11% of the dose is metabolized in the liver, but it is not significantly metabolized by cytochrome P450 enzymes. It is a moderate inhibitor of CYP2C9 and CYP3A4, and a strong inhibitor of CYP2C19.
Side Effects
Contraindications
- •Known hypersensitivity to fluconazole or any other azole antifungal agents or excipients of the product
- •Concomitant administration with terfenadine or cisapride (due to risk of severe arrhythmias and QTc prolongation)
- •Concomitant administration with drugs known to prolong the QT interval and metabolized by CYP3A4, such as quinidine and pimozide, in patients receiving multiple doses of fluconazole.
Drug Interactions
Warfarin
Fluconazole can increase the prothrombin time (PT) when co-administered with warfarin, necessitating careful monitoring of PT/INR.
Rifampicin
Rifampicin significantly decreases fluconazole concentrations, requiring an increase in fluconazole dosage.
Hydrochlorothiazide
Hydrochlorothiazide can increase plasma concentrations of fluconazole. No dose adjustment is usually needed.
Midazolam/Triazolam
Fluconazole significantly increases the plasma concentrations and effects of these benzodiazepines. Concurrent use should be avoided or dose adjusted with close monitoring.
Tacrolimus/Cyclosporine
Fluconazole can increase plasma concentrations of these immunosuppressants, leading to increased toxicity. Monitor drug levels and renal function.
Oral Hypoglycemics (sulfonylureas)
Fluconazole can prolong the half-life of oral sulfonylurea hypoglycemics, increasing the risk of hypoglycemia. Monitor blood glucose levels closely.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, supportive measures and symptomatic treatment should be initiated. Hemodialysis may reduce plasma concentrations by approximately 50% over a 3-hour session. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Fluconazole should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk; therefore, caution should be exercised when administered to a nursing mother. Consult a physician before use if pregnant or breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from the date of manufacture, specific to manufacturer.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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