Fluxit
Generic Name
Fluxit (hypothetical SSRI)
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fluxit 05 mg tablet | ৳ 5.02 | ৳ 50.20 |
Description
Overview of the medicine
Fluxit 5 mg Tablet is an antidepressant belonging to the Selective Serotonin Reuptake Inhibitor (SSRI) class. It is primarily used to treat major depressive disorder, anxiety disorders, and panic disorder by helping to restore the balance of serotonin in the brain.
Uses & Indications
Dosage
Adults
Initial dose 5 mg once daily, preferably in the morning. May be increased to 10 mg after 1 week. Max dose 20 mg daily.
Elderly
Initial dose 5 mg once daily. Max dose typically 10 mg daily.
Renal_impairment
No dose adjustment needed for mild to moderate impairment. Use with caution in severe impairment.
How to Take
Take orally, with or without food. It can be taken at any time of day, but consistency is recommended. Taking it in the morning may help avoid insomnia.
Mechanism of Action
Fluxit works by selectively inhibiting the reuptake of serotonin by neurons in the central nervous system. This increases the concentration of serotonin in the synaptic cleft, leading to enhanced serotonergic neurotransmission and improvement in mood and anxiety symptoms.
Pharmacokinetics
Onset
Clinical effects may take 2-4 weeks to become apparent.
Excretion
Mainly excreted in urine (approximately 60%) and feces (approximately 40%) as metabolites.
Half life
Approximately 20-30 hours, with an active metabolite having a slightly longer half-life.
Absorption
Well absorbed orally, peak plasma concentrations reached within 4-8 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP2D6 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Fluxit or any excipients
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOIs
- Concomitant use with pimozide
Drug Interactions
MAOIs
Potentially fatal serotonin syndrome.
NSAIDs
Increased risk of gastrointestinal bleeding.
Warfarin
Increased risk of bleeding due to potential inhibition of CYP2D6.
Tricyclic Antidepressants (TCAs)
Increased plasma levels of TCAs.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, tachycardia, tremor, agitation, and rarely, seizures or serotonin syndrome. Management is supportive, including maintaining an open airway, cardiac monitoring, and symptomatic treatment. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it may pass into breast milk and affect the infant. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Fluxit or any excipients
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOIs
- Concomitant use with pimozide
Drug Interactions
MAOIs
Potentially fatal serotonin syndrome.
NSAIDs
Increased risk of gastrointestinal bleeding.
Warfarin
Increased risk of bleeding due to potential inhibition of CYP2D6.
Tricyclic Antidepressants (TCAs)
Increased plasma levels of TCAs.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, tachycardia, tremor, agitation, and rarely, seizures or serotonin syndrome. Management is supportive, including maintaining an open airway, cardiac monitoring, and symptomatic treatment. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it may pass into breast milk and affect the infant. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 years from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by Regulatory Authority
Patent Status
Patent expired
Clinical Trials
Clinical trials demonstrated Fluxit's efficacy in reducing Hamilton Depression Rating Scale (HDRS) scores significantly compared to placebo, with a generally well-tolerated safety profile in adult patients with MDD.
Lab Monitoring
- Liver function tests (baseline and periodically)
- Renal function tests (for severe impairment)
- Serum sodium levels (especially in elderly)
- ECG (in patients with cardiac risk factors)
Doctor Notes
- Initiate treatment at the lowest effective dose and titrate slowly.
- Monitor for signs of serotonin syndrome, especially when co-administered with other serotonergic agents.
- Advise patients about the delayed onset of therapeutic effects and the importance of adherence.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking the medicine abruptly; gradual reduction is necessary to avoid withdrawal symptoms.
- Report any worsening of depression or suicidal thoughts to your doctor immediately.
- Avoid alcohol while on this medication.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Fluxit may cause dizziness, drowsiness, or blurred vision. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Engage in regular physical activity.
- Maintain a balanced diet.
- Practice stress-reduction techniques.
- Ensure adequate sleep.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.