Folison-Z
Generic Name
Folic Acid 5 mg + Zinc (as Zinc Sulfate Monohydrate)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| folison z 5 mg tablet | ৳ 2.50 | ৳ 25.00 |
Description
Overview of the medicine
Folison-Z 5 mg tablet is a combination supplement containing Folic Acid and Zinc. Folic Acid is a B vitamin essential for DNA synthesis, cell growth, and red blood cell formation, important for preventing neural tube defects during pregnancy and treating megaloblastic anemia. Zinc is an essential trace element crucial for immune function, wound healing, protein synthesis, and proper growth and development.
Uses & Indications
Dosage
Adults
Typically, one tablet daily, or as directed by a physician.
Elderly
No specific dose adjustment required, usually same as adults.
Renal_impairment
No specific dose adjustment for mild to moderate impairment. Consult a physician for severe impairment.
How to Take
Take orally with water, with or without food. Follow physician's instructions.
Mechanism of Action
Folic Acid is reduced to tetrahydrofolate, a coenzyme involved in single-carbon transfers in the synthesis of purines and pyrimidines, essential for DNA and RNA synthesis, and amino acid metabolism. Zinc acts as a cofactor for over 300 enzymes involved in various metabolic processes, immune function, gene expression, and oxidative stress protection.
Pharmacokinetics
Onset
Therapeutic effects are gradual, generally within days to weeks for deficiencies.
Excretion
Folic acid is excreted mainly via urine; excess amounts are excreted unchanged. Zinc is primarily excreted via feces, with minor renal excretion.
Half life
Folic acid: 3-9 hours. Zinc: Approximately 2-3 hours in plasma, but longer in tissues.
Absorption
Folic acid is well absorbed from the gastrointestinal tract, primarily from the duodenum and jejunum. Zinc absorption varies (10-40%) and is affected by food components.
Metabolism
Folic acid is metabolized in the liver to tetrahydrofolate and other active forms. Zinc is not metabolized but primarily involved in enzymatic reactions.
Side Effects
Contraindications
- Hypersensitivity to Folic Acid, Zinc, or any component of the formulation.
- Undiagnosed megaloblastic anemia where Vitamin B12 deficiency has not been excluded (as Folic Acid can mask B12 deficiency symptoms).
Drug Interactions
Methotrexate
Folic acid can interfere with the action of methotrexate, a folate antagonist. Avoid concurrent use or monitor closely.
Penicillamine
Zinc can reduce the absorption of penicillamine. Separate administration times.
Sulfasalazine
Can decrease folic acid absorption.
Iron supplements
High doses of iron can affect zinc absorption, and vice versa. Separate administration times.
Tetracyclines & Quinolones
Zinc can chelate with these antibiotics, reducing their absorption. Administer zinc at least 2 hours before or 4-6 hours after these antibiotics.
Antiepileptics (e.g., Phenytoin, Phenobarbital)
Folic acid can reduce plasma levels of certain antiepileptics, potentially decreasing their effectiveness. Dosage adjustments may be needed.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Folic acid has very low toxicity; large doses are generally well-tolerated with few side effects. Excessive zinc intake (above 40 mg/day for prolonged periods) can lead to copper deficiency, immune dysfunction, and gastrointestinal upset (nausea, vomiting, diarrhea, abdominal pain). Management is supportive and symptomatic.
Pregnancy & Lactation
Folic Acid is highly recommended before and during pregnancy to prevent neural tube defects. Both Folic Acid and Zinc are safe and often beneficial during pregnancy and lactation when taken at recommended doses. Consult a doctor for appropriate dosage.
Side Effects
Contraindications
- Hypersensitivity to Folic Acid, Zinc, or any component of the formulation.
- Undiagnosed megaloblastic anemia where Vitamin B12 deficiency has not been excluded (as Folic Acid can mask B12 deficiency symptoms).
Drug Interactions
Methotrexate
Folic acid can interfere with the action of methotrexate, a folate antagonist. Avoid concurrent use or monitor closely.
Penicillamine
Zinc can reduce the absorption of penicillamine. Separate administration times.
Sulfasalazine
Can decrease folic acid absorption.
Iron supplements
High doses of iron can affect zinc absorption, and vice versa. Separate administration times.
Tetracyclines & Quinolones
Zinc can chelate with these antibiotics, reducing their absorption. Administer zinc at least 2 hours before or 4-6 hours after these antibiotics.
Antiepileptics (e.g., Phenytoin, Phenobarbital)
Folic acid can reduce plasma levels of certain antiepileptics, potentially decreasing their effectiveness. Dosage adjustments may be needed.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Folic acid has very low toxicity; large doses are generally well-tolerated with few side effects. Excessive zinc intake (above 40 mg/day for prolonged periods) can lead to copper deficiency, immune dysfunction, and gastrointestinal upset (nausea, vomiting, diarrhea, abdominal pain). Management is supportive and symptomatic.
Pregnancy & Lactation
Folic Acid is highly recommended before and during pregnancy to prevent neural tube defects. Both Folic Acid and Zinc are safe and often beneficial during pregnancy and lactation when taken at recommended doses. Consult a doctor for appropriate dosage.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Available in pharmacies and drugstores nationwide.
Approval Status
Approved by national regulatory bodies (e.g., DGDA)
Patent Status
Off-patent (for active ingredients)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials support the efficacy and safety of Folic Acid and Zinc individually and in combination for their indicated uses.
Lab Monitoring
- Serum folate levels (if deficiency is suspected)
- Serum zinc levels (if deficiency or toxicity is suspected)
- Vitamin B12 levels (if megaloblastic anemia is present, to rule out B12 deficiency)
Doctor Notes
- Always assess for Vitamin B12 deficiency before initiating high-dose folic acid, especially in elderly patients or those with risk factors for B12 deficiency.
- Counsel patients on potential drug interactions, especially with antibiotics and antiepileptics.
- Advise on appropriate spacing of Folison-Z with other mineral supplements (e.g., iron, calcium) to optimize absorption.
Patient Guidelines
- Take the tablet whole with water. Do not crush or chew.
- Follow the prescribed dosage and duration, even if you feel better.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- If you experience any unusual symptoms, consult your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Folison-Z is generally not expected to impair the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in fruits, vegetables, and whole grains to support overall nutritional intake.
- Avoid smoking and excessive alcohol consumption, as these can affect nutrient absorption.
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