Fosamin
Generic Name
Fosfomycin Trometamol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fosamin 3 gm powder | ৳ 350.00 | N/A |
Description
Overview of the medicine
Fosfomycin is a broad-spectrum antibiotic used to treat acute uncomplicated urinary tract infections (UTIs) caused by susceptible bacteria. It is typically administered as a single oral dose.
Uses & Indications
Dosage
Adults
One sachet (3 gm of fosfomycin) dissolved in 90-120 mL of water and taken as a single oral dose, preferably on an empty stomach or 2-3 hours after food.
Elderly
No specific dose adjustment is needed for elderly patients with normal renal function. Use with caution in elderly patients with impaired renal function.
Renal_impairment
Contraindicated in patients with severe renal impairment (creatinine clearance <10 mL/min).
How to Take
Dissolve the entire contents of the sachet in 90-120 mL (approximately half a glass) of water. Stir to dissolve and drink immediately. Do not use hot water.
Mechanism of Action
Inhibits an early stage of bacterial cell wall synthesis by inactivating the enzyme UDP-N-acetylglucosamine enolpyruvyl transferase (MurA).
Pharmacokinetics
Onset
Within 2-4 hours of administration.
Excretion
Primarily excreted unchanged in the urine (around 50%) and feces (around 18%) within 72 hours.
Half life
Plasma half-life is approximately 4-8 hours; urinary half-life is longer.
Absorption
Rapidly absorbed after oral administration, converted to fosfomycin acid. Peak plasma concentrations reached within 2-4 hours. Bioavailability is about 37%.
Metabolism
Not extensively metabolized in the body.
Side Effects
Contraindications
- Known hypersensitivity to fosfomycin or any component of the formulation.
- Severe renal impairment (creatinine clearance <10 mL/min) or patients undergoing hemodialysis.
Drug Interactions
Metoclopramide
Concomitant administration of metoclopramide reduces the peak plasma concentration and urinary excretion of fosfomycin. Avoid co-administration.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include diarrhea, abdominal discomfort. In case of overdose, supportive care and symptomatic treatment should be administered. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. Fosfomycin is excreted in human milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Known hypersensitivity to fosfomycin or any component of the formulation.
- Severe renal impairment (creatinine clearance <10 mL/min) or patients undergoing hemodialysis.
Drug Interactions
Metoclopramide
Concomitant administration of metoclopramide reduces the peak plasma concentration and urinary excretion of fosfomycin. Avoid co-administration.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include diarrhea, abdominal discomfort. In case of overdose, supportive care and symptomatic treatment should be administered. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed. Fosfomycin is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Pharmacies and hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Ongoing clinical trials are exploring its efficacy against multi-drug resistant organisms and potential new indications.
Lab Monitoring
- Urine culture and susceptibility testing should be performed before and after treatment to verify bacterial eradication, especially if symptoms persist.
Doctor Notes
- Emphasize single-dose compliance for uncomplicated UTIs.
- Advise patients about potential reduction in efficacy if taken with metoclopramide.
- Consider urine culture for persistent symptoms.
Patient Guidelines
- Take the entire contents of the sachet at once.
- Dissolve in water completely before drinking.
- Do not crush or chew the powder.
- Take on an empty stomach for best absorption.
Missed Dose Advice
As Fosamin is a single-dose treatment, a missed dose is not applicable. Ensure the full dose is taken as prescribed.
Driving Precautions
Fosfomycin generally does not affect the ability to drive or operate machinery. However, if you experience dizziness, avoid such activities.
Lifestyle Advice
- Drink plenty of fluids to help flush out bacteria.
- Maintain good personal hygiene to prevent recurrent UTIs.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.