Fosul
Generic Name
Fosfomycin
Manufacturer
Acme Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fosul 500 mg capsule | ৳ 2.25 | N/A |
Description
Overview of the medicine
Fosul 500 mg Capsule contains Fosfomycin, a broad-spectrum antibiotic used to treat various bacterial infections, primarily uncomplicated urinary tract infections (UTIs). It is bactericidal and works by inhibiting bacterial cell wall synthesis.
Uses & Indications
Dosage
Adults
For uncomplicated UTIs: 500 mg orally 2-3 times daily for 5-7 days. Dosage may vary based on the specific infection and physician's discretion.
Elderly
No specific dose adjustment is required for elderly patients with normal renal function. However, dose adjustment may be necessary if renal impairment is present.
Renal_impairment
Dosage should be adjusted in patients with severe renal impairment. Consult product monograph for specific guidelines.
How to Take
Take Fosul 500 mg Capsule orally with a glass of water, with or without food. It is important to complete the full course of treatment as prescribed by your doctor, even if you start to feel better.
Mechanism of Action
Fosfomycin is a bactericidal antibiotic that interferes with bacterial cell wall synthesis. It inhibits the enzyme UDP-N-acetylglucosamine-3-enolpyruvyl transferase (MurA), which is responsible for the first step in peptidoglycan synthesis, a crucial component of the bacterial cell wall.
Pharmacokinetics
Onset
Peak plasma levels reached within 2-4 hours. Therapeutic concentrations in urine are achieved rapidly.
Excretion
Primarily excreted unchanged by the kidneys into the urine, reaching high concentrations.
Half life
Plasma half-life is approximately 2-5 hours, depending on the formulation and renal function.
Absorption
Rapidly absorbed orally, with peak plasma concentrations occurring 2-4 hours post-administration. Bioavailability can vary with different salt forms.
Metabolism
Fosfomycin is minimally metabolized in the body.
Side Effects
Contraindications
- Known hypersensitivity to fosfomycin or any component of the formulation.
- Patients with severe renal impairment (creatinine clearance <10 mL/min) unless closely monitored or with appropriate dose adjustment.
Drug Interactions
Metoclopramide
Concomitant use with metoclopramide can reduce the absorption of fosfomycin, decreasing its serum and urinary concentrations. Avoid concurrent use or consider alternative antiemetics.
Other Antibiotics
Co-administration with other antibiotics may have synergistic or antagonistic effects. Consult a healthcare professional before combining antibiotics.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive measures should be initiated. There is no specific antidote. Forced diuresis may enhance elimination.
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Fosfomycin is excreted into breast milk; caution is advised when administering to a nursing mother. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Fosfomycin has been extensively studied in clinical trials for its efficacy and safety in treating urinary tract infections and other susceptible bacterial infections. Ongoing research continues to evaluate its role in various clinical settings.
Lab Monitoring
- Renal function tests (e.g., creatinine clearance) should be monitored, especially in patients with pre-existing renal impairment or during prolonged therapy.
Doctor Notes
- Emphasize the importance of completing the full course of therapy to prevent relapse and resistance.
- Consider renal function for dose adjustments, especially in elderly or renally impaired patients.
- Counsel patients on potential side effects like diarrhea and advise them to seek medical attention if severe.
Patient Guidelines
- Complete the entire course of medication as prescribed, even if symptoms improve.
- Stay well-hydrated by drinking plenty of fluids.
- Report any persistent or severe side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Fosul may cause dizziness or visual disturbances in some individuals. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain good personal hygiene to help prevent recurrent UTIs.
- Consider lifestyle changes such as adequate fluid intake and proper voiding habits.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.