Take Frudema 40 mg Tablet orally, usually once or twice daily. It can be taken with or without food, but consistency is advised. Take it in the morning to avoid nighttime urination.

Furosemide acts on the thick ascending limb of the loop of Henle in the kidneys, inhibiting the Na-K-2Cl cotransporter. This prevents the reabsorption of sodium, potassium, and chloride ions, leading to increased excretion of water, sodium, chloride, magnesium, and calcium.

• •Anuria
• •Hypersensitivity to furosemide or sulfonamides
• •Hepatic coma or precoma
• •Severe electrolyte depletion (e.g., hypokalemia, hyponatremia)

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Symptoms of overdose include dehydration, electrolyte imbalance (hypokalemia, hyponatremia, hypochloremic alkalosis), hypotension, and cardiovascular collapse. Treatment involves fluid and electrolyte replacement, and supportive care.

Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Furosemide is excreted in breast milk and may inhibit lactation; caution is advised during breastfeeding.