Fucort
Generic Name
Fusidic Acid + Betamethasone Valerate
Manufacturer
Acme Laboratories Ltd. (Bangladesh)
Country
Bangladesh (for local production)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| fucort 2 1 cream | ৳ 125.00 | N/A |
Description
Overview of the medicine
Fucort cream is a topical preparation indicated for the treatment of inflammatory skin conditions, such as eczema or dermatitis, where bacterial infection is present or suspected. It combines the potent anti-inflammatory action of betamethasone valerate with the antibacterial activity of fusidic acid.
Uses & Indications
Dosage
Adults
Apply a small amount to the affected area 2 to 3 times daily. A course of treatment should not normally exceed 2 weeks.
Elderly
No special dosage adjustments are required.
Renal_impairment
No special dosage adjustments are required as systemic absorption is minimal.
How to Take
For topical use only. Apply thinly and gently rub onto the affected skin area.
Mechanism of Action
Fusidic acid inhibits bacterial protein synthesis by interfering with elongation factor G, leading to a bacteriostatic effect against susceptible bacteria, primarily Gram-positive organisms like Staphylococcus aureus. Betamethasone valerate is a potent topical corticosteroid that acts by inducing phospholipase A2 inhibitory proteins, thus preventing the release of arachidonic acid and subsequently inhibiting the formation of inflammatory mediators like prostaglandins and leukotrienes. This results in anti-inflammatory, antipruritic, and vasoconstrictive effects.
Pharmacokinetics
Onset
Onset of clinical effect is typically within a few days of starting treatment.
Excretion
Fusidic acid is mainly excreted in the bile, while betamethasone and its metabolites are primarily excreted in the urine.
Half life
Not precisely determined for topical application due to minimal systemic absorption.
Absorption
Minimal systemic absorption of fusidic acid and betamethasone valerate occurs after topical application to intact skin. Absorption may increase from damaged skin or under occlusive dressings.
Metabolism
Absorbed fusidic acid is primarily metabolized in the liver and betamethasone valerate is also metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to fusidic acid, betamethasone valerate, or any excipients
- Primary skin infections caused by fungi, viruses, or mycobacteria
- Perioral dermatitis and acne rosacea
- Acne vulgaris
- Ulcerative conditions
Drug Interactions
No significant drug interactions are expected with topical administration due to minimal systemic absorption. However, caution should be exercised if used concurrently with other topical preparations.
Interaction description
Storage
Store below 25-30°C. Do not freeze. Protect from light and moisture. Keep out of reach of children.
Overdose
Topical overdose is unlikely to cause systemic toxicity due to limited absorption. Excessive prolonged use may lead to local adverse effects (e.g., skin atrophy, striae) and potential systemic corticosteroid effects, requiring symptomatic treatment.
Pregnancy & Lactation
Use with caution during pregnancy and lactation. Avoid extensive application or prolonged use. Consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to fusidic acid, betamethasone valerate, or any excipients
- Primary skin infections caused by fungi, viruses, or mycobacteria
- Perioral dermatitis and acne rosacea
- Acne vulgaris
- Ulcerative conditions
Drug Interactions
No significant drug interactions are expected with topical administration due to minimal systemic absorption. However, caution should be exercised if used concurrently with other topical preparations.
Interaction description
Storage
Store below 25-30°C. Do not freeze. Protect from light and moisture. Keep out of reach of children.
Overdose
Topical overdose is unlikely to cause systemic toxicity due to limited absorption. Excessive prolonged use may lead to local adverse effects (e.g., skin atrophy, striae) and potential systemic corticosteroid effects, requiring symptomatic treatment.
Pregnancy & Lactation
Use with caution during pregnancy and lactation. Avoid extensive application or prolonged use. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies
Approval Status
Approved globally, including DGDA in Bangladesh
Patent Status
Off-patent
Clinical Trials
Clinical trials have demonstrated the efficacy and safety of fusidic acid and betamethasone valerate combination in treating various infected dermatoses.
Lab Monitoring
- No specific routine lab monitoring is required for topical use. For extensive or prolonged use, monitoring for adrenal suppression may be considered.
Doctor Notes
- Advise patients on proper application technique and duration of use.
- Educate patients about potential local side effects and when to seek medical advice.
- Avoid prescribing for viral or fungal infections, as corticosteroids can worsen these conditions.
Patient Guidelines
- Use only on the skin as directed by your doctor.
- Do not use for longer than the prescribed duration (usually not more than 2 weeks).
- Avoid contact with eyes, mouth, and other mucous membranes.
- Wash hands thoroughly after application.
- Do not use under occlusive dressings unless advised by a doctor.
- Inform your doctor if your condition worsens or does not improve.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.
Driving Precautions
Fucort cream has no known effect on the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good skin hygiene.
- Avoid scratching affected areas to prevent further infection.
- Wear loose, cotton clothing to allow skin to breathe.
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Global Brand Names
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