Adults

Adults: 250-500 mg twice daily depending on the infection severity.

Elderly

Elderly: Dosage similar to adults, but caution and dosage adjustment may be necessary in patients with impaired renal function.

Renal_impairment

Renal impairment: Dosage should be reduced based on creatinine clearance.

Onset

Onset of action typically within 1-2 hours.

Excretion

Excreted unchanged in the urine by glomerular filtration and tubular secretion.

Half life

Approximately 1 to 1.5 hours.

Absorption

Rapidly absorbed from the gastrointestinal tract and rapidly hydrolyzed by esterases to cefuroxime. Absorption is enhanced when taken with food.

Metabolism

Cefuroxime itself is not metabolized. The axetil ester is hydrolyzed to cefuroxime.

Probenecid

Concomitant administration with probenecid increases the area under the serum concentration-time curve (AUC) of cefuroxime and peak serum concentrations, prolonging the renal excretion.

Oral Contraceptives

Cefuroxime may affect gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral contraceptives.

Antacids/H2-receptor antagonists

Drugs that reduce gastric acidity may result in a lower bioavailability of cefuroxime axetil.