Furoxim
Generic Name
Cefuroxime Axetil
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| furoxim 250 mg tablet | ৳ 25.00 | ৳ 100.00 |
Description
Overview of the medicine
Cefuroxime axetil is a broad-spectrum cephalosporin antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
Typical dose is 250 mg to 500 mg twice daily, depending on the severity and type of infection. For most infections, 250 mg twice daily. For severe infections or lower respiratory tract infections, 500 mg twice daily. Duration usually 5-10 days.
Elderly
Similar to adult dosage, but caution should be exercised in patients with renal impairment. Renal function should be monitored.
Renal_impairment
Dosage adjustment is required for patients with severe renal impairment (creatinine clearance < 30 mL/min). For CrCl 10-29 mL/min, 250 mg once daily. For CrCl < 10 mL/min, 250 mg every 48 hours. Hemodialysis patients should take an additional dose after each dialysis.
How to Take
Take orally, preferably with food to enhance absorption and reduce gastrointestinal discomfort. Do not crush or chew the tablet.
Mechanism of Action
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Peak plasma concentrations reached approximately 2-3 hours after oral administration.
Excretion
Primarily excreted unchanged in urine by glomerular filtration and tubular secretion, within 24 hours.
Half life
Approximately 1.2 to 1.5 hours.
Absorption
Well absorbed from the gastrointestinal tract after oral administration, enhanced with food. Bioavailability is approximately 37% to 52%.
Metabolism
Hydrolyzed by esterases in the intestinal mucosa and blood to release cefuroxime. Cefuroxime itself is not significantly metabolized.
Side Effects
Contraindications
- Known hypersensitivity to cefuroxime, other cephalosporins, or any component of the formulation
- History of severe hypersensitivity reaction (e.g., anaphylaxis) to any other type of beta-lactam antibacterial agent (e.g., penicillins, carbapenems)
Drug Interactions
Warfarin
Although not definitive, some cephalosporins may potentiate the anticoagulant effect of warfarin. INR monitoring is advisable.
Probenecid
Concomitant administration with probenecid increases the area under the serum concentration versus time curve by 50%.
Oral Contraceptives
Cefuroxime may affect gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral contraceptives.
Antacids/H2 blockers
Drugs that reduce gastric acidity may reduce the bioavailability of cefuroxime axetil. It is recommended to take cefuroxime axetil at least 1 hour before or 2 hours after antacids.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Overdosage of cephalosporins can cause cerebral irritation leading to convulsions. Management includes symptomatic and supportive treatment. Hemodialysis and peritoneal dialysis may be useful in enhancing elimination.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not revealed evidence of impaired fertility or harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefuroxime is excreted in human milk in small amounts; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years (refer to manufacturer's specific packaging for exact details)
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of cefuroxime axetil in treating a wide range of bacterial infections in both adult and pediatric populations.
Lab Monitoring
- Periodic assessment of renal and hepatic function during prolonged therapy.
- Monitoring for potential changes in blood counts (e.g., leukopenia, thrombocytopenia) if long-term use.
Doctor Notes
- Emphasize the importance of completing the full course of antibiotics to prevent resistance.
- Counsel patients on potential gastrointestinal side effects and advise taking with food.
- Be aware of potential for C. difficile-associated diarrhea, especially with prolonged use.
Patient Guidelines
- Take the full prescribed course of medicine, even if you feel better, to prevent recurrence and development of antibiotic resistance.
- Take with food to improve absorption and minimize stomach upset.
- Do not share this medicine with others, even if they have similar symptoms.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause dizziness. Patients should be warned about driving or operating machinery if they experience dizziness.
Lifestyle Advice
- Drink plenty of fluids to stay hydrated.
- Maintain good hygiene to prevent spread of infection.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.