g-aspirin
Generic Name
Aspirin (Acetylsalicylic Acid) 300 mg Tablet
Manufacturer
Hypothetical Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| g aspirin 300 mg tablet | ৳ 0.60 | ৳ 6.00 |
Description
Overview of the medicine
Aspirin (acetylsalicylic acid) is a non-steroidal anti-inflammatory drug (NSAID) and an antiplatelet agent used for pain relief, fever reduction, anti-inflammatory effects, and prevention of cardiovascular events like heart attacks and strokes.
Uses & Indications
Dosage
Adults
For antiplatelet effect: 75-325 mg once daily. For pain/fever/inflammation (300 mg dose): 300-900 mg every 4-6 hours, maximum 4g/day. Specific indication dosages vary.
Elderly
Caution advised due to increased risk of adverse effects, especially gastrointestinal bleeding and renal impairment. Lower doses may be appropriate.
Renal_impairment
Use with caution; dosage adjustment may be required. Avoid in severe renal impairment (CrCl < 10 mL/min).
How to Take
Oral administration. Take with food or milk to minimize gastrointestinal upset. Swallow whole with a full glass of water. Do not crush or chew enteric-coated tablets.
Mechanism of Action
Aspirin inhibits cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins (mediators of pain, fever, and inflammation) and thromboxane A2 (a potent inducer of platelet aggregation).
Pharmacokinetics
Onset
Analgesic/Antipyretic: 30-60 minutes; Antiplatelet: 1-2 hours for full effect.
Excretion
Primarily excreted renally as free salicylic acid and its metabolites (salicyluric acid, salicylate glucuronides, and gentisic acid). Renal excretion is dose-dependent and pH-dependent.
Half life
Aspirin itself has a very short half-life (15-20 minutes) as it is rapidly hydrolyzed to salicylic acid. Salicylic acid has a half-life of 2-4.5 hours at therapeutic doses, which can extend up to 15-30 hours with high doses.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract, primarily in the stomach and upper small intestine. Peak plasma levels of salicylate occur within 1-2 hours.
Metabolism
Rapidly hydrolyzed in the gastrointestinal tract, liver, and blood to salicylic acid, which is then conjugated with glucuronic acid and glycine, or hydroxylated.
Side Effects
Contraindications
- •Known hypersensitivity to aspirin or other NSAIDs
- •Asthma, rhinitis, and nasal polyps (aspirin triad)
- •Children and adolescents with viral infections (risk of Reye's syndrome)
- •Gastrointestinal ulcers or bleeding history
- •Severe renal or hepatic impairment
- •Severe heart failure
- •Third trimester of pregnancy
- •Coagulation disorders (e.g., hemophilia)
Drug Interactions
Methotrexate
Increased methotrexate toxicity due to reduced renal clearance.
Other NSAIDs
Increased risk of GI bleeding and ulceration.
Corticosteroids
Increased risk of GI ulcers/bleeding.
Diuretics/ACE Inhibitors
Reduced antihypertensive and diuretic effects.
Uricosurics (e.g., Probenecid)
Reduced uricosuric effect.
Anticoagulants (e.g., Warfarin, Heparin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children.
Overdose
Symptoms include tinnitus, dizziness, headache, nausea, vomiting, confusion, hyperventilation, and metabolic acidosis. Severe cases can lead to coma, convulsions, and respiratory failure. Management involves gastric lavage, activated charcoal, urine alkalinization, hemodialysis, and symptomatic/supportive care.
Pregnancy & Lactation
Pregnancy: Category C in 1st/2nd trimester, D in 3rd trimester (due to risk of premature closure of ductus arteriosus). Avoid unless benefits outweigh risks. Lactation: Aspirin and its metabolites are excreted in breast milk; use with caution, avoid high doses.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals, retail stores
Approval Status
Approved by major regulatory bodies (e.g., FDA, MHRA, DGDA)
Patent Status
Generic (Patent expired for Aspirin)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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