g-co-aspirin
Generic Name
g-co-aspirin-75-mg-tablet
Manufacturer
Generic Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| g co aspirin 75 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Aspirin 75 mg is a non-steroidal anti-inflammatory drug (NSAID) primarily used as an antiplatelet agent to prevent blood clot formation, especially in cardiovascular conditions. It works by inhibiting platelet aggregation.
Uses & Indications
Dosage
Adults
Typically 75 mg once daily for antiplatelet effect, or as directed by a physician. In acute coronary syndromes, loading doses may be higher.
Elderly
Similar to adult dose, but caution advised due to increased risk of bleeding and renal impairment. Close monitoring is recommended.
Renal_impairment
Use with caution. Dosage adjustment may be required in severe renal impairment (e.g., GFR < 10 mL/min). Not recommended in end-stage renal disease without medical supervision.
How to Take
Take orally, usually once daily. It is recommended to take with or after food to minimize gastrointestinal upset. Swallow enteric-coated tablets whole; do not crush, chew, or break them.
Mechanism of Action
Aspirin irreversibly inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes. At low doses (like 75mg), it primarily inhibits COX-1 in platelets, thereby reducing thromboxane A2 (TXA2) production. TXA2 is a potent platelet aggregator and vasoconstrictor, so its reduction leads to an antiplatelet effect.
Pharmacokinetics
Onset
Antiplatelet effect begins within 1 hour.
Excretion
Primarily excreted in the urine as salicylic acid and its glucuronide and glycine conjugates.
Half life
Parent drug (acetylsalicylic acid) half-life is 15-20 minutes. Active metabolite (salicylic acid) half-life is 2-3 hours at low doses, increasing with dose.
Absorption
Rapidly absorbed from the gastrointestinal tract, primarily from the stomach and small intestine. Peak plasma levels of parent drug within 0.25-2 hours.
Metabolism
Rapidly hydrolyzed to salicylic acid by esterases in the GI mucosa, liver, and red blood cells. Salicylic acid is then conjugated in the liver.
Side Effects
Contraindications
- Known hypersensitivity to aspirin or other NSAIDs (e.g., ibuprofen, naproxen).
- Active peptic ulcer disease or gastrointestinal bleeding.
- Hemophilia or other severe bleeding disorders.
- Severe renal or hepatic impairment.
- Asthma, rhinitis, and nasal polyps (Samter's triad) triggered by NSAIDs.
- Children and adolescents with viral infections (e.g., chickenpox, flu) due to risk of Reye's syndrome.
- Third trimester of pregnancy due to risk of premature closure of ductus arteriosus.
Drug Interactions
Alcohol
Increased risk of gastrointestinal bleeding.
SSRIs/SNRIs
Increased risk of gastrointestinal bleeding.
Methotrexate
Increased methotrexate toxicity by reducing its renal clearance.
Sulfonylureas
Enhanced hypoglycemic effect.
Corticosteroids
Increased risk of gastrointestinal ulceration and bleeding.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin, Heparin)
Increased risk of bleeding.
Other NSAIDs (e.g., Ibuprofen, Naproxen)
Increased risk of GI bleeding and may interfere with aspirin's antiplatelet effect if taken together.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms include tinnitus (ringing in ears), hearing loss, dizziness, nausea, vomiting, abdominal pain, hyperventilation, and metabolic acidosis. Severe overdose can lead to delirium, seizures, coma, respiratory depression, and cardiovascular collapse. Treatment involves gastric decontamination (activated charcoal), correction of fluid and electrolyte imbalances, alkalization of urine, and hemodialysis in severe cases.
Pregnancy & Lactation
Pregnancy: Category D in the third trimester due to risks to the fetus (premature closure of ductus arteriosus, antiplatelet effects). In early pregnancy, low-dose aspirin may be used for specific indications (e.g., pre-eclampsia prevention) under strict medical supervision. Lactation: Small amounts of aspirin and its metabolites are excreted in breast milk. Generally considered safe for occasional use of low doses, but regular high-dose use is not recommended due to potential for adverse effects in the infant (e.g., Reye's syndrome risk). Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture, specific to batch.
Availability
Pharmacies, Hospitals
Approval Status
Approved (Widely used and approved)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials, including large-scale randomized controlled trials (e.g., Physician's Health Study, Women's Health Study), have firmly established the efficacy and safety of low-dose aspirin for primary and secondary prevention of cardiovascular diseases.
Lab Monitoring
- Complete Blood Count (CBC) with differential, especially hemoglobin and hematocrit for signs of bleeding if long-term use.
- Renal function tests (e.g., serum creatinine, BUN) periodically.
- Liver function tests (e.g., ALT, AST) if signs of hepatic impairment.
- Stool occult blood test (for occult GI bleeding).
- Prothrombin Time (PT) / International Normalized Ratio (INR) if concurrent use of anticoagulants.
Doctor Notes
- Emphasize patient education regarding bleeding risks and symptoms, and the importance of adherence.
- Consider co-prescription of gastroprotective agents (e.g., Proton Pump Inhibitors) for patients at high risk of GI bleeding (e.g., history of ulcer, concomitant corticosteroid use).
- Counsel patients about potential drug interactions, especially with other antiplatelet agents, anticoagulants, and NSAIDs.
- Regularly assess renal function and complete blood count in patients on long-term aspirin therapy.
Patient Guidelines
- Take Aspirin 75mg exactly as prescribed by your doctor. Do not stop taking it or change the dose without consulting your doctor.
- Report any unusual bleeding (e.g., black or tarry stools, coffee-ground vomit, prolonged nosebleeds) or bruising to your doctor immediately.
- Avoid taking other NSAIDs (like ibuprofen) or over-the-counter pain relievers without consulting your doctor, as this can increase bleeding risk.
- Inform your doctor or dentist that you are taking aspirin before any surgery or dental procedures.
- Do not give aspirin to children or teenagers with flu-like symptoms, chickenpox, or other viral illnesses without consulting a doctor due to the risk of Reye's syndrome.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Aspirin 75mg generally has no or negligible influence on the ability to drive and use machines. However, if you experience dizziness, visual disturbances, or any other side effects that impair your concentration, avoid driving or operating machinery until you feel well.
Lifestyle Advice
- Maintain a heart-healthy lifestyle including a balanced diet, regular physical activity, and stress management.
- Quit smoking and limit alcohol intake, as these can increase cardiovascular risk and the risk of gastrointestinal bleeding when taking aspirin.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.