Cleanse and debride the burn wound thoroughly prior to application. Apply a thin layer (2-4 mm thick) directly to the affected area using a sterile gloved hand or spatula. The cream should be re-applied daily and whenever necessary to maintain continuous coverage.

Silver sulfadiazine dissociates into silver ions and sulfadiazine. Silver ions exert antimicrobial effects by binding to bacterial DNA and cell walls, disrupting their integrity. Sulfadiazine inhibits bacterial folic acid synthesis by interfering with dihydropteroate synthase, leading to bacteriostasis.

• •Hypersensitivity to silver sulfadiazine, sulfonamides, or any component of the cream.
• •Premature infants or neonates (risk of kernicterus).
• •Pregnancy near term (risk of kernicterus in the infant).
• •Breastfeeding women of infants less than 2 months old.
• •Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency (risk of hemolysis).

Store at room temperature (below 25-30°C). Do not freeze. Keep away from direct sunlight and moisture. Keep out of reach of children.

Systemic toxicity from topical overdose is rare due to minimal absorption. If accidental ingestion or excessive application over large areas leads to systemic effects, manage symptomatically and supportively (e.g., fluid administration, monitoring of renal function, blood counts).

Pregnancy Category B, but contraindicated near term due to potential for kernicterus in the infant. Use only if potential benefit outweighs risk. Contraindicated in breastfeeding women of infants less than 2 months old.