Gabapre
Generic Name
gabapre
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| gabapre 25 mg capsule | ৳ 10.00 | ৳ 100.00 |
| gabapre 50 mg capsule | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Gabapre (Gabapentin) is an anticonvulsant and neuropathic pain agent used to treat partial seizures, postherpetic neuralgia, and restless legs syndrome.
Uses & Indications
Dosage
Adults
For partial seizures: Initial dose 300 mg three times daily (TID), titrated up to 900-3600 mg/day. For postherpetic neuralgia: Initial 300 mg on Day 1, 300 mg BID on Day 2, 300 mg TID on Day 3, titrated up to 1800 mg/day. For restless legs syndrome: Initial 300 mg once daily, titrated up to 1800 mg/day.
Elderly
Lower initial doses and careful titration are recommended due to potential age-related decrease in renal function.
Renal_impairment
Dose adjustment is necessary based on creatinine clearance. Lower doses are required for patients with impaired renal function.
How to Take
Take orally with or without food. Capsules should be swallowed whole. Extended-release tablets should not be crushed, chewed, or cut.
Mechanism of Action
Its exact mechanism of action is unknown, but it is thought to modulate the release of excitatory neurotransmitters by binding to the alpha-2-delta subunit of voltage-gated calcium channels. It does not bind to GABA receptors.
Pharmacokinetics
Onset
Therapeutic effects may begin within days to weeks.
Excretion
Excreted unchanged in the urine.
Half life
Approximately 5-7 hours in adults.
Absorption
Absorption is not dose-proportional and involves a saturable transport system, leading to decreased bioavailability with increasing doses.
Metabolism
Not significantly metabolized in humans.
Side Effects
Contraindications
- •Known hypersensitivity to gabapentin or any component of the formulation
Drug Interactions
Antacids
May decrease gabapentin bioavailability; take gabapentin at least 2 hours after antacid administration.
Opioids (e.g., Morphine)
May increase gabapentin levels and enhance CNS depressive effects. Monitor for signs of sedation and respiratory depression.
Alcohol and other CNS depressants
May increase CNS depression.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, dizziness, ataxia, lethargy, and mild diarrhea. Management is primarily supportive; hemodialysis can be used to remove gabapentin.
Pregnancy & Lactation
Pregnancy Category C. Gabapentin has been shown to be teratogenic in animals. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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